Para-dichlorobenzene toxicity - A review of potential neurotoxic manifestations

Divyanshu Dubey, Vibhash D. Sharma, Steven E. Pass, Anshudha Sawhney, Olaf Stüve

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Background: Para-dichlorobenzene (PDCB) is an active ingredient of mothballs, deodorizers and fumigants. Due to the easy availability of this chemical, there is a considerable risk for accidental or intentional toxic exposure. Recently, multiple cases of PDCB toxicity due to mothball ingestion were reported. PDCB toxicity can affect multiple organ systems including liver, kidneys, skin, lung and the central nervous system (CNS). CNS toxicity often results in leukoencephalopathy and heterogeneous neurological manifestations. Objectives: The objective of this study was to illustrate the clinical presentation, imaging findings, diagnosis and management of PDCB toxicity. Methods: We carried out a literature review of the pharmacological and toxicological properties of PDCB. Conclusions: PDCB and other aromatic hydrocarbons are capable of CNS tissue damage and in promoting functional neurological decline. While very little is currently known about prevalence of PDCB addiction, it cannot be ruled out that its illicit use among young people is under-recognized. The number of cases of PDCB toxicity might also rise due to the increasing industrial and domestic use of this chemical.

Original languageEnglish (US)
Pages (from-to)177-187
Number of pages11
JournalTherapeutic Advances in Neurological Disorders
Volume7
Issue number3
DOIs
StatePublished - 2014

Fingerprint

Central Nervous System
Leukoencephalopathies
Aromatic Hydrocarbons
Nerve Tissue
4-dichlorobenzene
Poisons
Neurologic Manifestations
Toxicology
Eating
Pharmacology
Kidney
Lung
Skin
Liver

Keywords

  • aromatic hydrocarbons
  • demyelination
  • leukoencephalopathy
  • mothballs
  • neurotoxicity
  • Paradichlorobenzene

ASJC Scopus subject areas

  • Pharmacology
  • Clinical Neurology
  • Neurology

Cite this

Para-dichlorobenzene toxicity - A review of potential neurotoxic manifestations. / Dubey, Divyanshu; Sharma, Vibhash D.; Pass, Steven E.; Sawhney, Anshudha; Stüve, Olaf.

In: Therapeutic Advances in Neurological Disorders, Vol. 7, No. 3, 2014, p. 177-187.

Research output: Contribution to journalArticle

Dubey, Divyanshu ; Sharma, Vibhash D. ; Pass, Steven E. ; Sawhney, Anshudha ; Stüve, Olaf. / Para-dichlorobenzene toxicity - A review of potential neurotoxic manifestations. In: Therapeutic Advances in Neurological Disorders. 2014 ; Vol. 7, No. 3. pp. 177-187.
@article{646fd72012ef433fa5bb653542e2f966,
title = "Para-dichlorobenzene toxicity - A review of potential neurotoxic manifestations",
abstract = "Background: Para-dichlorobenzene (PDCB) is an active ingredient of mothballs, deodorizers and fumigants. Due to the easy availability of this chemical, there is a considerable risk for accidental or intentional toxic exposure. Recently, multiple cases of PDCB toxicity due to mothball ingestion were reported. PDCB toxicity can affect multiple organ systems including liver, kidneys, skin, lung and the central nervous system (CNS). CNS toxicity often results in leukoencephalopathy and heterogeneous neurological manifestations. Objectives: The objective of this study was to illustrate the clinical presentation, imaging findings, diagnosis and management of PDCB toxicity. Methods: We carried out a literature review of the pharmacological and toxicological properties of PDCB. Conclusions: PDCB and other aromatic hydrocarbons are capable of CNS tissue damage and in promoting functional neurological decline. While very little is currently known about prevalence of PDCB addiction, it cannot be ruled out that its illicit use among young people is under-recognized. The number of cases of PDCB toxicity might also rise due to the increasing industrial and domestic use of this chemical.",
keywords = "aromatic hydrocarbons, demyelination, leukoencephalopathy, mothballs, neurotoxicity, Paradichlorobenzene",
author = "Divyanshu Dubey and Sharma, {Vibhash D.} and Pass, {Steven E.} and Anshudha Sawhney and Olaf St{\"u}ve",
year = "2014",
doi = "10.1177/1756285614521889",
language = "English (US)",
volume = "7",
pages = "177--187",
journal = "Therapeutic Advances in Neurological Disorders",
issn = "1756-2856",
publisher = "SAGE Publications Ltd",
number = "3",

}

TY - JOUR

T1 - Para-dichlorobenzene toxicity - A review of potential neurotoxic manifestations

AU - Dubey, Divyanshu

AU - Sharma, Vibhash D.

AU - Pass, Steven E.

AU - Sawhney, Anshudha

AU - Stüve, Olaf

PY - 2014

Y1 - 2014

N2 - Background: Para-dichlorobenzene (PDCB) is an active ingredient of mothballs, deodorizers and fumigants. Due to the easy availability of this chemical, there is a considerable risk for accidental or intentional toxic exposure. Recently, multiple cases of PDCB toxicity due to mothball ingestion were reported. PDCB toxicity can affect multiple organ systems including liver, kidneys, skin, lung and the central nervous system (CNS). CNS toxicity often results in leukoencephalopathy and heterogeneous neurological manifestations. Objectives: The objective of this study was to illustrate the clinical presentation, imaging findings, diagnosis and management of PDCB toxicity. Methods: We carried out a literature review of the pharmacological and toxicological properties of PDCB. Conclusions: PDCB and other aromatic hydrocarbons are capable of CNS tissue damage and in promoting functional neurological decline. While very little is currently known about prevalence of PDCB addiction, it cannot be ruled out that its illicit use among young people is under-recognized. The number of cases of PDCB toxicity might also rise due to the increasing industrial and domestic use of this chemical.

AB - Background: Para-dichlorobenzene (PDCB) is an active ingredient of mothballs, deodorizers and fumigants. Due to the easy availability of this chemical, there is a considerable risk for accidental or intentional toxic exposure. Recently, multiple cases of PDCB toxicity due to mothball ingestion were reported. PDCB toxicity can affect multiple organ systems including liver, kidneys, skin, lung and the central nervous system (CNS). CNS toxicity often results in leukoencephalopathy and heterogeneous neurological manifestations. Objectives: The objective of this study was to illustrate the clinical presentation, imaging findings, diagnosis and management of PDCB toxicity. Methods: We carried out a literature review of the pharmacological and toxicological properties of PDCB. Conclusions: PDCB and other aromatic hydrocarbons are capable of CNS tissue damage and in promoting functional neurological decline. While very little is currently known about prevalence of PDCB addiction, it cannot be ruled out that its illicit use among young people is under-recognized. The number of cases of PDCB toxicity might also rise due to the increasing industrial and domestic use of this chemical.

KW - aromatic hydrocarbons

KW - demyelination

KW - leukoencephalopathy

KW - mothballs

KW - neurotoxicity

KW - Paradichlorobenzene

UR - http://www.scopus.com/inward/record.url?scp=84899410738&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84899410738&partnerID=8YFLogxK

U2 - 10.1177/1756285614521889

DO - 10.1177/1756285614521889

M3 - Article

C2 - 24790648

AN - SCOPUS:84899410738

VL - 7

SP - 177

EP - 187

JO - Therapeutic Advances in Neurological Disorders

JF - Therapeutic Advances in Neurological Disorders

SN - 1756-2856

IS - 3

ER -