PARACEST Agents: Modulating MRI Contrast via Water Proton Exchange

Shanrong Zhang, Matthew Merritt, Donald E. Woessner, Robert E. Lenkinski, A. Dean Sherry

Research output: Contribution to journalArticle

349 Scopus citations

Abstract

Scientific interest in optimizing the properties of gadolinium (III) complexes as MRI contrast agents has led to many new insights into lanthanide ion coordination chemistry in the last two decades. Among these was the surprising observation that water exchange in lanthanide (III) derivatives of DOTA can be modulated dramatically by judicious choice of ligand side chain and Ln3+ ionic radii. This resulted in the discovery of paramagnetic CEST agents for altering MRI image contrast based upon the chemical exchange saturation transfer mechanism. The goal of this article is to review the factors that govern water molecule and water proton exchange in these complexes and to compare the potential sensitivity of PARACEST agents versus Gd 3+-based T1 relaxation agents for altering tissue contrast.

Original languageEnglish (US)
Pages (from-to)783-790
Number of pages8
JournalAccounts of Chemical Research
Volume36
Issue number10
DOIs
StatePublished - Oct 1 2003

ASJC Scopus subject areas

  • Chemistry(all)

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