PARACEST contrast agents

Dean Sherry, Mark Woods

Research output: Chapter in Book/Report/Conference proceedingChapter

6 Scopus citations

Abstract

The previous chapter introduced the concept of using chemical exchange saturation transfer (CEST) methods to produce contrast in magnetic resonance (MR) images. Since MR image intensity is largely determined by the water content of tissues and the relaxation characteristics of that water, any molecule that is in chemical exchange with water can potentially be used to transfer saturated spins into the pool of water protons, and hence used to initiate CEST contrast. In biology, this includes any molecule, large or small, that contains an exchangeable proton such as –NH, –OH, –SH, –PO4H, or, in unusual circumstances, –CO2H. The protons in such groups typically have nuclear magnetic resonance (NMR) chemical shifts that differ from tissue water by <5 ppm. This makes it difficult, if not impossible, to saturate one of these exchangeable spins without partial saturation of at least some of the bulk water spins as well. More will be presented on this later. One could expand the choices of exchangeable spins from simple proton systems (–NH, –OH, etc.) to a water molecule (H2O) if the chemical shift degeneracy between water molecules in different chemical environments or compartments could be lifted. As we shall see, this is the role fulfilled by paramagnetic metal ions and, in particular, the trivalent lanthanide (III) ions.

Original languageEnglish (US)
Title of host publicationMolecular and Cellular MR Imaging
PublisherCRC Press
Pages101-122
Number of pages22
ISBN (Electronic)9781420004090
ISBN (Print)0849372526, 9780849372520
StatePublished - Jan 1 2007

ASJC Scopus subject areas

  • Medicine(all)
  • Biochemistry, Genetics and Molecular Biology(all)

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  • Cite this

    Sherry, D., & Woods, M. (2007). PARACEST contrast agents. In Molecular and Cellular MR Imaging (pp. 101-122). CRC Press.