Paracetamol poisoning unmasking factor VII deficiency

Andrew P. Chilton; Tariq Hussain; Elwyn Elias

doi:10.1097/00042737-200204000-00019

Paracetamol poisoning unmasking factor VII deficiency

Andrew P. Chilton, Tariq Hussain, Elwyn Elias

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

We report on an 18-year-old woman who took an impulsive overdose of paracetamol. The admission international normalized ratio (INR) was prolonged which resulted in her being transferred to a specialist hepatology unit. Her clinical condition and laboratory parameters did not correlate; this prompted investigation into her coagulation profile, which revealed a factor VII deficiency and explained the observed abnormalities of an elevated INR, normal partial thromboplastin time and normal liver function. There are no other reports of factor VII deficiency being identified as a result of paracetamol overdose.

Original language	English (US)
Pages (from-to)	441-443
Number of pages	3
Journal	European Journal of Gastroenterology and Hepatology
Volume	14
Issue number	4
DOIs	https://doi.org/10.1097/00042737-200204000-00019
State	Published - 2002

Keywords

Acetaminophen poisoning
Factor VII deficiency
Liver failure
Paracetamol toxicity

ASJC Scopus subject areas

Hepatology
Gastroenterology

Access to Document

10.1097/00042737-200204000-00019

Cite this

@article{666bc0717934436f93f69b2c15125a3e,

title = "Paracetamol poisoning unmasking factor VII deficiency",

abstract = "We report on an 18-year-old woman who took an impulsive overdose of paracetamol. The admission international normalized ratio (INR) was prolonged which resulted in her being transferred to a specialist hepatology unit. Her clinical condition and laboratory parameters did not correlate; this prompted investigation into her coagulation profile, which revealed a factor VII deficiency and explained the observed abnormalities of an elevated INR, normal partial thromboplastin time and normal liver function. There are no other reports of factor VII deficiency being identified as a result of paracetamol overdose.",

keywords = "Acetaminophen poisoning, Factor VII deficiency, Liver failure, Paracetamol toxicity",

author = "Chilton, {Andrew P.} and Tariq Hussain and Elwyn Elias",

year = "2002",

doi = "10.1097/00042737-200204000-00019",

language = "English (US)",

volume = "14",

pages = "441--443",

journal = "European Journal of Gastroenterology and Hepatology",

issn = "0954-691X",

publisher = "Lippincott Williams and Wilkins",

number = "4",

}

TY - JOUR

T1 - Paracetamol poisoning unmasking factor VII deficiency

AU - Chilton, Andrew P.

AU - Hussain, Tariq

AU - Elias, Elwyn

PY - 2002

Y1 - 2002

N2 - We report on an 18-year-old woman who took an impulsive overdose of paracetamol. The admission international normalized ratio (INR) was prolonged which resulted in her being transferred to a specialist hepatology unit. Her clinical condition and laboratory parameters did not correlate; this prompted investigation into her coagulation profile, which revealed a factor VII deficiency and explained the observed abnormalities of an elevated INR, normal partial thromboplastin time and normal liver function. There are no other reports of factor VII deficiency being identified as a result of paracetamol overdose.

AB - We report on an 18-year-old woman who took an impulsive overdose of paracetamol. The admission international normalized ratio (INR) was prolonged which resulted in her being transferred to a specialist hepatology unit. Her clinical condition and laboratory parameters did not correlate; this prompted investigation into her coagulation profile, which revealed a factor VII deficiency and explained the observed abnormalities of an elevated INR, normal partial thromboplastin time and normal liver function. There are no other reports of factor VII deficiency being identified as a result of paracetamol overdose.

KW - Acetaminophen poisoning

KW - Factor VII deficiency

KW - Liver failure

KW - Paracetamol toxicity

UR - http://www.scopus.com/inward/record.url?scp=0036228347&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0036228347&partnerID=8YFLogxK

U2 - 10.1097/00042737-200204000-00019

DO - 10.1097/00042737-200204000-00019

M3 - Article

C2 - 11943961

AN - SCOPUS:0036228347

SN - 0954-691X

VL - 14

SP - 441

EP - 443

JO - European Journal of Gastroenterology and Hepatology

JF - European Journal of Gastroenterology and Hepatology

IS - 4

ER -

Paracetamol poisoning unmasking factor VII deficiency

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this