PARADOXICAL EXPANSION OF INTRACRANIAL TUBERCULOMAS DURING CHEMOTHERAPY

S. T. Chambers; C. Record; W. A. Hendrickse; Peter Rudge; Hillas Smith

doi:10.1016/S0140-6736(84)90478-1

PARADOXICAL EXPANSION OF INTRACRANIAL TUBERCULOMAS DURING CHEMOTHERAPY

S. T. Chambers, C. Record, W. A. Hendrickse, Peter Rudge, Hillas Smith

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Abstract

4 patients with tuberculosis, 3 of whom had tuberculous meningitis, were noted to have tuberculomas on computed tomographic scanning. During antituberculous chemotherapy the intracranial lesions increased in size in all 4 patients at a time when the clinical state and cerebrospinal-fluid abnormalities were improving; in 2 of the patients the regional lymph nodes also enlarged greatly. Though the expansion of the cerebral lesions caused anxiety and led to some changes in chemotherapy, the lesions eventually diminished in size.

Original language	English (US)
Pages (from-to)	181-184
Number of pages	4
Journal	The Lancet
Volume	324
Issue number	8396
DOIs	https://doi.org/10.1016/S0140-6736(84)90478-1
State	Published - Jul 28 1984

ASJC Scopus subject areas

General Medicine

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abstract = "4 patients with tuberculosis, 3 of whom had tuberculous meningitis, were noted to have tuberculomas on computed tomographic scanning. During antituberculous chemotherapy the intracranial lesions increased in size in all 4 patients at a time when the clinical state and cerebrospinal-fluid abnormalities were improving; in 2 of the patients the regional lymph nodes also enlarged greatly. Though the expansion of the cerebral lesions caused anxiety and led to some changes in chemotherapy, the lesions eventually diminished in size.",

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AU - Rudge, Peter

AU - Smith, Hillas

PY - 1984/7/28

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N2 - 4 patients with tuberculosis, 3 of whom had tuberculous meningitis, were noted to have tuberculomas on computed tomographic scanning. During antituberculous chemotherapy the intracranial lesions increased in size in all 4 patients at a time when the clinical state and cerebrospinal-fluid abnormalities were improving; in 2 of the patients the regional lymph nodes also enlarged greatly. Though the expansion of the cerebral lesions caused anxiety and led to some changes in chemotherapy, the lesions eventually diminished in size.

AB - 4 patients with tuberculosis, 3 of whom had tuberculous meningitis, were noted to have tuberculomas on computed tomographic scanning. During antituberculous chemotherapy the intracranial lesions increased in size in all 4 patients at a time when the clinical state and cerebrospinal-fluid abnormalities were improving; in 2 of the patients the regional lymph nodes also enlarged greatly. Though the expansion of the cerebral lesions caused anxiety and led to some changes in chemotherapy, the lesions eventually diminished in size.

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PARADOXICAL EXPANSION OF INTRACRANIAL TUBERCULOMAS DURING CHEMOTHERAPY

Abstract

ASJC Scopus subject areas

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