Parallel wavefront measurements in ultrasound pulse guided digital phase conjugation

Reto Fiolka, Ke Si, Meng Cui

Research output: Contribution to journalArticle

12 Scopus citations

Abstract

Ultrasound pulse guided digital phase conjugation has emerged to realize fluorescence imaging inside random scattering media. Its major limitation is the slow imaging speed, as a new wavefront needs to be measured for each voxel. Therefore 3D or even 2D imaging can be time consuming. For practical applications on biological systems, we need to accelerate the imaging process by orders of magnitude. Here we propose and experimentally demonstrate a parallel wavefront measurement scheme towards such a goal. Multiple focused ultrasound pulses of different carrier frequencies can be simultaneously launched inside a scattering medium. Heterodyne interferometry is used to measure all of the wavefronts originating from every sound focus in parallel. We use these wavefronts in sequence to rapidly excite fluorescence at all the voxels defined by the focused ultrasound pulses. In this report, we employed a commercially available sound transducer to generate two sound foci in parallel, doubled the wavefront measurement speed, and reduced the mechanical scanning steps of the sound transducer to half.

Original languageEnglish (US)
Pages (from-to)24827-24834
Number of pages8
JournalOptics Express
Volume20
Issue number22
DOIs
StatePublished - Oct 22 2012

ASJC Scopus subject areas

  • Atomic and Molecular Physics, and Optics

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