Paraneoplastic chorea associated with CRMP-5 neuronal antibody and lung carcinoma

Steven Vernino, Paul Tuite, Charles H. Adler, James F. Meschia, Bradley F. Boeve, Peter Boasberg, Joseph E. Parisi, Vanda A. Lennon

Research output: Contribution to journalArticle

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Abstract

Paraneoplastic chorea is described in 16 patients: 11 with limited small-cell carcinoma, 2 with lung cancer revealed by imaging, 1 with renal cell carcinoma, and 1 with lymphoma. All had CRMP-5-IgG; 6 also had ANNA-1 (anti-Hu), including 1 without evident cancer. Chorea was the initial and most prominent symptom in 11 patients, asymmetric or unilateral in 5 patients, and part of a multifocal syndrome in 14 patients. Basal ganglia abnormalities were revealed by magnetic resonance imaging and at autopsy (as perivascular inflammation and microglial activation). Four patients improved with chemotherapy, and 2 improved with intravenous methylprednisolone.

Original languageEnglish (US)
Pages (from-to)625-630
Number of pages6
JournalAnnals of Neurology
Volume51
Issue number5
DOIs
StatePublished - 2002

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Chorea
Carcinoma
Lung
Antibodies
Small Cell Carcinoma
Methylprednisolone
Basal Ganglia
Autopsy
Lymphoma
Lung Neoplasms
Immunoglobulin G
Magnetic Resonance Imaging
Inflammation
Drug Therapy
Neoplasms

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Vernino, S., Tuite, P., Adler, C. H., Meschia, J. F., Boeve, B. F., Boasberg, P., ... Lennon, V. A. (2002). Paraneoplastic chorea associated with CRMP-5 neuronal antibody and lung carcinoma. Annals of Neurology, 51(5), 625-630. https://doi.org/10.1002/ana.10178

Paraneoplastic chorea associated with CRMP-5 neuronal antibody and lung carcinoma. / Vernino, Steven; Tuite, Paul; Adler, Charles H.; Meschia, James F.; Boeve, Bradley F.; Boasberg, Peter; Parisi, Joseph E.; Lennon, Vanda A.

In: Annals of Neurology, Vol. 51, No. 5, 2002, p. 625-630.

Research output: Contribution to journalArticle

Vernino, S, Tuite, P, Adler, CH, Meschia, JF, Boeve, BF, Boasberg, P, Parisi, JE & Lennon, VA 2002, 'Paraneoplastic chorea associated with CRMP-5 neuronal antibody and lung carcinoma', Annals of Neurology, vol. 51, no. 5, pp. 625-630. https://doi.org/10.1002/ana.10178
Vernino, Steven ; Tuite, Paul ; Adler, Charles H. ; Meschia, James F. ; Boeve, Bradley F. ; Boasberg, Peter ; Parisi, Joseph E. ; Lennon, Vanda A. / Paraneoplastic chorea associated with CRMP-5 neuronal antibody and lung carcinoma. In: Annals of Neurology. 2002 ; Vol. 51, No. 5. pp. 625-630.
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AU - Boasberg, Peter

AU - Parisi, Joseph E.

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