Paraneoplastic neurological autoimmunity associated with ANNA-1 autoantibody and thymoma

Steven Vernino, Eric R. Eggenberger, Lisa R. Rogers, Vanda A. Lennon

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

Neurologic autoimmunity frequently occurs with thymoma, particularly myasthenia gravis and skeletal muscle-specific autoantibodies. Type 1 antineuronal nuclear antibody (ANNA-1/"anti-Hu"), which is recognized as an immunoglobulin G marker of small-cell lung carcinoma, has not been reported with thymoma. The authors identified four patients (three under age 40) with ANNA-1 and a paraneoplastic neurologic complication of thymoma. Retrospective testing of stored serum from 172 patients with thymoma revealed ANNA-1 in 3%. This report extends the oncologic implications of ANNA-1 seropositivity.

Original languageEnglish (US)
Pages (from-to)929-932
Number of pages4
JournalNeurology
Volume59
Issue number6
StatePublished - Sep 24 2002

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Thymoma
Autoimmunity
Autoantibodies
Nervous System
Myasthenia Gravis
Small Cell Lung Carcinoma
Skeletal Muscle
Immunoglobulin G
Antibodies
Serum

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Vernino, S., Eggenberger, E. R., Rogers, L. R., & Lennon, V. A. (2002). Paraneoplastic neurological autoimmunity associated with ANNA-1 autoantibody and thymoma. Neurology, 59(6), 929-932.

Paraneoplastic neurological autoimmunity associated with ANNA-1 autoantibody and thymoma. / Vernino, Steven; Eggenberger, Eric R.; Rogers, Lisa R.; Lennon, Vanda A.

In: Neurology, Vol. 59, No. 6, 24.09.2002, p. 929-932.

Research output: Contribution to journalArticle

Vernino, S, Eggenberger, ER, Rogers, LR & Lennon, VA 2002, 'Paraneoplastic neurological autoimmunity associated with ANNA-1 autoantibody and thymoma', Neurology, vol. 59, no. 6, pp. 929-932.
Vernino, Steven ; Eggenberger, Eric R. ; Rogers, Lisa R. ; Lennon, Vanda A. / Paraneoplastic neurological autoimmunity associated with ANNA-1 autoantibody and thymoma. In: Neurology. 2002 ; Vol. 59, No. 6. pp. 929-932.
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