Parasagittal biopsies are more important as part of an initial biopsy strategy than as part of a repeat biopsy strategy: Observations from a unique population

A. R. Patel, J. S. Jones, M. Zhou, L. Schoenfield, C. Magi-Galluzzi

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Comparing the yield of parasagittal biopsies during initial saturation biopsy to the yield during repeat saturation biopsy for detection of prostate cancer. Office-based saturation biopsy (24 cores) with periprostatic lidocaine block was performed in 139 consecutive men who had never previously undergone prostate biopsy. Indication for biopsy was elevated prostate-specific antigen >2.5ng/dl. Biopsy specimens were obtained and marked by location for histological examination. Subanalysis of patients from this unique study was performed to compare the location of saturation biopsy cancer detection in these patients to a cohort of 100 patients who had previously undergone biopsy with nonmalignant findings. In the initial biopsy group, cancer was detected in 62/139 patients (44.6%). Breakdown of cancer location demonstrated unique parasagittal cancers in 9/62 patients (14.5%). Laterally base cancer was found exclusively in 22/62 patients (35.5%). For the repeat biopsy population, cancer was found in 25 patients (25%); no patients (0%) had exclusive parasagittal cancer. To our knowledge, this is the first study to demonstrate a difference in the location of positive cores between initial and repeat biopsy status. The exclusive parasagittal cancer detection rate decreases significantly in the repeat biopsy population when using the same biopsy method. Our findings support including traditional template parasagittal sampling of the prostate on first-time biopsy in addition to lateral cores typical of extended field biopsies for a total of 10-12 cores. However, parasagittal sampling adds negligible additional information in repeat biopsy; thus we recommend obtaining primarily laterally based cores for repeat biopsy.

Original languageEnglish (US)
Pages (from-to)352-355
Number of pages4
JournalProstate Cancer and Prostatic Diseases
Volume10
Issue number4
DOIs
StatePublished - Dec 1 2007

Fingerprint

Biopsy
Population
Neoplasms
Prostate
Prostate-Specific Antigen
Lidocaine
Prostatic Neoplasms

ASJC Scopus subject areas

  • Oncology
  • Urology
  • Cancer Research

Cite this

Parasagittal biopsies are more important as part of an initial biopsy strategy than as part of a repeat biopsy strategy : Observations from a unique population. / Patel, A. R.; Jones, J. S.; Zhou, M.; Schoenfield, L.; Magi-Galluzzi, C.

In: Prostate Cancer and Prostatic Diseases, Vol. 10, No. 4, 01.12.2007, p. 352-355.

Research output: Contribution to journalArticle

@article{d8a9212f7de74161bc0de038254b20c3,
title = "Parasagittal biopsies are more important as part of an initial biopsy strategy than as part of a repeat biopsy strategy: Observations from a unique population",
abstract = "Comparing the yield of parasagittal biopsies during initial saturation biopsy to the yield during repeat saturation biopsy for detection of prostate cancer. Office-based saturation biopsy (24 cores) with periprostatic lidocaine block was performed in 139 consecutive men who had never previously undergone prostate biopsy. Indication for biopsy was elevated prostate-specific antigen >2.5ng/dl. Biopsy specimens were obtained and marked by location for histological examination. Subanalysis of patients from this unique study was performed to compare the location of saturation biopsy cancer detection in these patients to a cohort of 100 patients who had previously undergone biopsy with nonmalignant findings. In the initial biopsy group, cancer was detected in 62/139 patients (44.6{\%}). Breakdown of cancer location demonstrated unique parasagittal cancers in 9/62 patients (14.5{\%}). Laterally base cancer was found exclusively in 22/62 patients (35.5{\%}). For the repeat biopsy population, cancer was found in 25 patients (25{\%}); no patients (0{\%}) had exclusive parasagittal cancer. To our knowledge, this is the first study to demonstrate a difference in the location of positive cores between initial and repeat biopsy status. The exclusive parasagittal cancer detection rate decreases significantly in the repeat biopsy population when using the same biopsy method. Our findings support including traditional template parasagittal sampling of the prostate on first-time biopsy in addition to lateral cores typical of extended field biopsies for a total of 10-12 cores. However, parasagittal sampling adds negligible additional information in repeat biopsy; thus we recommend obtaining primarily laterally based cores for repeat biopsy.",
author = "Patel, {A. R.} and Jones, {J. S.} and M. Zhou and L. Schoenfield and C. Magi-Galluzzi",
year = "2007",
month = "12",
day = "1",
doi = "10.1038/sj.pcan.4500966",
language = "English (US)",
volume = "10",
pages = "352--355",
journal = "Prostate Cancer and Prostatic Diseases",
issn = "1365-7852",
publisher = "Nature Publishing Group",
number = "4",

}

TY - JOUR

T1 - Parasagittal biopsies are more important as part of an initial biopsy strategy than as part of a repeat biopsy strategy

T2 - Observations from a unique population

AU - Patel, A. R.

AU - Jones, J. S.

AU - Zhou, M.

AU - Schoenfield, L.

AU - Magi-Galluzzi, C.

PY - 2007/12/1

Y1 - 2007/12/1

N2 - Comparing the yield of parasagittal biopsies during initial saturation biopsy to the yield during repeat saturation biopsy for detection of prostate cancer. Office-based saturation biopsy (24 cores) with periprostatic lidocaine block was performed in 139 consecutive men who had never previously undergone prostate biopsy. Indication for biopsy was elevated prostate-specific antigen >2.5ng/dl. Biopsy specimens were obtained and marked by location for histological examination. Subanalysis of patients from this unique study was performed to compare the location of saturation biopsy cancer detection in these patients to a cohort of 100 patients who had previously undergone biopsy with nonmalignant findings. In the initial biopsy group, cancer was detected in 62/139 patients (44.6%). Breakdown of cancer location demonstrated unique parasagittal cancers in 9/62 patients (14.5%). Laterally base cancer was found exclusively in 22/62 patients (35.5%). For the repeat biopsy population, cancer was found in 25 patients (25%); no patients (0%) had exclusive parasagittal cancer. To our knowledge, this is the first study to demonstrate a difference in the location of positive cores between initial and repeat biopsy status. The exclusive parasagittal cancer detection rate decreases significantly in the repeat biopsy population when using the same biopsy method. Our findings support including traditional template parasagittal sampling of the prostate on first-time biopsy in addition to lateral cores typical of extended field biopsies for a total of 10-12 cores. However, parasagittal sampling adds negligible additional information in repeat biopsy; thus we recommend obtaining primarily laterally based cores for repeat biopsy.

AB - Comparing the yield of parasagittal biopsies during initial saturation biopsy to the yield during repeat saturation biopsy for detection of prostate cancer. Office-based saturation biopsy (24 cores) with periprostatic lidocaine block was performed in 139 consecutive men who had never previously undergone prostate biopsy. Indication for biopsy was elevated prostate-specific antigen >2.5ng/dl. Biopsy specimens were obtained and marked by location for histological examination. Subanalysis of patients from this unique study was performed to compare the location of saturation biopsy cancer detection in these patients to a cohort of 100 patients who had previously undergone biopsy with nonmalignant findings. In the initial biopsy group, cancer was detected in 62/139 patients (44.6%). Breakdown of cancer location demonstrated unique parasagittal cancers in 9/62 patients (14.5%). Laterally base cancer was found exclusively in 22/62 patients (35.5%). For the repeat biopsy population, cancer was found in 25 patients (25%); no patients (0%) had exclusive parasagittal cancer. To our knowledge, this is the first study to demonstrate a difference in the location of positive cores between initial and repeat biopsy status. The exclusive parasagittal cancer detection rate decreases significantly in the repeat biopsy population when using the same biopsy method. Our findings support including traditional template parasagittal sampling of the prostate on first-time biopsy in addition to lateral cores typical of extended field biopsies for a total of 10-12 cores. However, parasagittal sampling adds negligible additional information in repeat biopsy; thus we recommend obtaining primarily laterally based cores for repeat biopsy.

UR - http://www.scopus.com/inward/record.url?scp=36949018005&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=36949018005&partnerID=8YFLogxK

U2 - 10.1038/sj.pcan.4500966

DO - 10.1038/sj.pcan.4500966

M3 - Article

C2 - 17420763

AN - SCOPUS:36949018005

VL - 10

SP - 352

EP - 355

JO - Prostate Cancer and Prostatic Diseases

JF - Prostate Cancer and Prostatic Diseases

SN - 1365-7852

IS - 4

ER -