Paratesticular rhabdomyosarcoma: Delayed effects of multimodality therapy and implications for current management

Lorie L. Hughes, Maria J. Baruzzi, Raul C. Ribeiro, Gregory D. Ayers, Bhaskar Rao, David M. Parham, Charles B. Pratt, Larry E. Kun

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

Background. The combined modalities of surgery, chemotherapy, and radiation therapy have greatly improved the survival rate in childhood paratesticular rhabdomyosarcoma, but the incidence of complications and late side effects is a cause for concern. Methods. We reviewed the records of 18 patients treated for paratesticular rhabdomyosarcoma at St. Jude Children's Research Hospital between 1962 and 1989. Patients with Group I disease were treated with orchiectomy, retroperitoneal lymph node dissection, and multiagent chemotherapy; more advanced cases also received radiation therapy with concurrent chemotherapy. Results. Sequelae included esophageal and common bile duct stricture, inguinal nerve entrapment syndrome, and small bowel obstruction. Short stature was found in all children whose spines were irradiated via para‐aortic fields (34–37 Gy) prior to puberty. Two of 18 patients died from treatment complications and one from progressive disease. Conclusions. Multimodality treatment offers an excellent prognosis in paratesticular rhabdomyosarcoma, but is associated with significant morbidity and mortality rates. A discussion of therapy components and their application to disease stages suggests possible approaches to optimizing treatment for this therapy‐sensitive malignancy.

Original languageEnglish (US)
Pages (from-to)476-482
Number of pages7
JournalCancer
Volume73
Issue number2
DOIs
StatePublished - Jan 1 1994

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Rhabdomyosarcoma
Drug Therapy
Radiotherapy
Nerve Compression Syndromes
Orchiectomy
Groin
Common Bile Duct
Therapeutics
Puberty
Lymph Node Excision
Pathologic Constriction
Spine
Survival Rate
Morbidity
Mortality
Incidence
Research
Neoplasms

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

Paratesticular rhabdomyosarcoma : Delayed effects of multimodality therapy and implications for current management. / Hughes, Lorie L.; Baruzzi, Maria J.; Ribeiro, Raul C.; Ayers, Gregory D.; Rao, Bhaskar; Parham, David M.; Pratt, Charles B.; Kun, Larry E.

In: Cancer, Vol. 73, No. 2, 01.01.1994, p. 476-482.

Research output: Contribution to journalArticle

Hughes, Lorie L. ; Baruzzi, Maria J. ; Ribeiro, Raul C. ; Ayers, Gregory D. ; Rao, Bhaskar ; Parham, David M. ; Pratt, Charles B. ; Kun, Larry E. / Paratesticular rhabdomyosarcoma : Delayed effects of multimodality therapy and implications for current management. In: Cancer. 1994 ; Vol. 73, No. 2. pp. 476-482.
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