Parental hyperdynamic circulation predicts insulin resistance in offspring

The Tecumseh Offspring Study

Paolo Palatini, Olga Vriz, Shawna Nesbitt, John Amerena, Silja Majahalme, Mariaconsuelo Valentini, Stevo Julius

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

Controversy surrounds the pathogenetic mechanisms of the relationship between hyperdynamic circulation and insulin resistance. Two hundred eight children and young adults (mean age, 17.2 ± 3.0 years; range, 11 to 26 years) from the Tecumseh Offspring Study whose parents had been assessed with Doppler echocardiography at the age of 34 years during the previous Tecumseh Blood Pressure Study were considered for this analysis. Offspring data were stratified according to tertiles of parental cardiac index. Parents in the top cardiac index tertile had increased heart rate (P=0.001), stroke volume (P=0.0001), left ventricular fractional shortening (P=0.02), and plasma epinephrine (P=0.02) compared with parents in the other tertiles. Body mass index (BMI) and blood pressure were similar in all groups. Offspring of parents with a high cardiac index had greater BMI (P=0.001), skinfold thickness (P=0.008), and waist/hip ratio (P=0.02), higher diastolic blood pressure (P=0.02) and plasma insulin level (P=0.001), and higher heart rate during Stroop's color test (P=0.02) than offspring of parents with a lower cardiac index. In a multivariate regression analysis, offspring BMI was predicted by parental BMI and cardiac index (P=0.0001 and 0.003, respectively). The mother-child relationship explained most of the cardiac index-BMI association. In summary, parental hyperdynamic circulation was an important predictor of overweight, abnormal fat distribution, increased blood pressure, and hyperinsulinemia in offspring. Our results illustrate the complexity of interaction between a genetic tendency and its phenotypic expression. We speculate that the degree of β-adrenergic responsiveness may be a major determinant of the phenotypic differences between the parents and offspring found in this study.

Original languageEnglish (US)
Pages (from-to)769-774
Number of pages6
JournalHypertension
Volume33
Issue number3
StatePublished - Mar 1999

Fingerprint

Insulin Resistance
Parents
Body Mass Index
Blood Pressure
Heart Rate
Stroop Test
Mother-Child Relations
Skinfold Thickness
Waist-Hip Ratio
Doppler Echocardiography
Hyperinsulinism
Stroke Volume
Adrenergic Agents
Epinephrine
Young Adult
Multivariate Analysis
Color
Fats
Regression Analysis
Insulin

Keywords

  • Heart rate
  • Hemodynamics
  • Hypertension
  • Insulin
  • Obesity
  • Sympathetic tone

ASJC Scopus subject areas

  • Internal Medicine

Cite this

Palatini, P., Vriz, O., Nesbitt, S., Amerena, J., Majahalme, S., Valentini, M., & Julius, S. (1999). Parental hyperdynamic circulation predicts insulin resistance in offspring: The Tecumseh Offspring Study. Hypertension, 33(3), 769-774.

Parental hyperdynamic circulation predicts insulin resistance in offspring : The Tecumseh Offspring Study. / Palatini, Paolo; Vriz, Olga; Nesbitt, Shawna; Amerena, John; Majahalme, Silja; Valentini, Mariaconsuelo; Julius, Stevo.

In: Hypertension, Vol. 33, No. 3, 03.1999, p. 769-774.

Research output: Contribution to journalArticle

Palatini, P, Vriz, O, Nesbitt, S, Amerena, J, Majahalme, S, Valentini, M & Julius, S 1999, 'Parental hyperdynamic circulation predicts insulin resistance in offspring: The Tecumseh Offspring Study', Hypertension, vol. 33, no. 3, pp. 769-774.
Palatini P, Vriz O, Nesbitt S, Amerena J, Majahalme S, Valentini M et al. Parental hyperdynamic circulation predicts insulin resistance in offspring: The Tecumseh Offspring Study. Hypertension. 1999 Mar;33(3):769-774.
Palatini, Paolo ; Vriz, Olga ; Nesbitt, Shawna ; Amerena, John ; Majahalme, Silja ; Valentini, Mariaconsuelo ; Julius, Stevo. / Parental hyperdynamic circulation predicts insulin resistance in offspring : The Tecumseh Offspring Study. In: Hypertension. 1999 ; Vol. 33, No. 3. pp. 769-774.
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