Parkinson's disease: A role for the immune system

Dwight C. German, Todd Eagar, Patricia K. Sonsalla

Research output: Contribution to journalReview article

3 Scopus citations

Abstract

Parkinson's disease (PD) is a progressive neurodegenerative disorder associated with the loss of catecholaminergic neurons in several brain regions. The motor symptoms of the disease are related to degeneration of the midbrain dopaminergic neurons, which occurs some time after the disease has begun. Both the innate and adaptive immune systems appear to play a role in the neurodegenerative process, and may contribute to disease progression. Here we review the neuropathology of PD with attention focused on the involvement of the innate immune cells (microglia) and the adaptive immune cells (T lymphocytes). In addition, we discuss animal models of the disease with emphasis on a progressive rat model which allows a detailed analysis of how the immune system contributes to neurodegeneration both during early and late stages of degeneration. Finally, for the early detection and treatment of PD, we discuss immunotherapy approaches.

Original languageEnglish (US)
Pages (from-to)340-349
Number of pages10
JournalCurrent Molecular Pharmacology
Volume5
Issue number3
DOIs
StatePublished - Dec 1 2012

Keywords

  • Dopamine
  • Glia
  • Inflammation
  • MPTP
  • Neurodegeneration
  • Peptoids
  • T cells

ASJC Scopus subject areas

  • Molecular Medicine
  • Pharmacology
  • Drug Discovery

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