PARP goes transcription

W. Lee Kraus, John T. Lis

Research output: Contribution to journalArticle

410 Citations (Scopus)

Abstract

PARP-1, an enzyme that catalyzes the attachment of ADP ribose units to target proteins, plays at least two important roles in transcription regulation. First, PARP-1 modifies histones and creates an anionic poly(ADPribose) matrix that binds histones, thereby promoting the decondensation of higher-order chromatin structures. Second, PARP-1 acts as a component of enhancer/promoter regulatory complexes. Recent studies have shown that both of these activities are critical for gene regulation in vivo.

Original languageEnglish (US)
Pages (from-to)677-683
Number of pages7
JournalCell
Volume113
Issue number6
DOIs
StatePublished - Jun 13 2003

Fingerprint

Adenosine Diphosphate Ribose
Transcription
Histones
Gene expression
Chromatin
Enzymes
Genes
Proteins

ASJC Scopus subject areas

  • Cell Biology
  • Molecular Biology

Cite this

PARP goes transcription. / Kraus, W. Lee; Lis, John T.

In: Cell, Vol. 113, No. 6, 13.06.2003, p. 677-683.

Research output: Contribution to journalArticle

Kraus, W. Lee ; Lis, John T. / PARP goes transcription. In: Cell. 2003 ; Vol. 113, No. 6. pp. 677-683.
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