PARP goes transcription

W. Lee Kraus, John T. Lis

Research output: Contribution to journalReview article

421 Scopus citations

Abstract

PARP-1, an enzyme that catalyzes the attachment of ADP ribose units to target proteins, plays at least two important roles in transcription regulation. First, PARP-1 modifies histones and creates an anionic poly(ADPribose) matrix that binds histones, thereby promoting the decondensation of higher-order chromatin structures. Second, PARP-1 acts as a component of enhancer/promoter regulatory complexes. Recent studies have shown that both of these activities are critical for gene regulation in vivo.

Original languageEnglish (US)
Pages (from-to)677-683
Number of pages7
JournalCell
Volume113
Issue number6
DOIs
StatePublished - Jun 13 2003

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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