Partial reversal of barbiturate anesthesia by dopamine antagonism: An electroencephalographic study

Christopher M. Sinton, Christine J. Goeller

Research output: Contribution to journalArticle

1 Scopus citations

Abstract

The D-1 dopamine antagonist, SCH 23390, was administered to rats under barbiturate anesthesia. Recording of the power frequency spectrum of the electroencephalogram (EEG) showed that the D-1 antagonist shifted the relative power in the EEG to higher frequencies. In contrast, a relatively selective D-2 antagonist, haloperidol, administered under the same conditions, had no effect. These results suggest that SCH 23390 can partially reverse barbiturate anesthesia, and imply that central dopamine, acting at the D-1 site, might modulate this type of anesthetic.

Original languageEnglish (US)
Pages (from-to)835-837
Number of pages3
JournalBrain Research Bulletin
Volume21
Issue number5
DOIs
StatePublished - Nov 1988

Keywords

  • D-1
  • D-2
  • EEG
  • Haloperidol
  • Inactin
  • Ketanserin
  • Nembutal
  • SCH 23390

ASJC Scopus subject areas

  • Neuroscience(all)

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