TY - JOUR
T1 - Partially Mixed Selectivity in Human Posterior Parietal Association Cortex
AU - Zhang, Carey Y.
AU - Aflalo, Tyson
AU - Revechkis, Boris
AU - Rosario, Emily R.
AU - Ouellette, Debra
AU - Pouratian, Nader
AU - Andersen, Richard A.
N1 - Funding Information:
This work was supported by the National Institute of Health (R01EY015545), the Tianqiao and Chrissy Chen Brain-machine Interface Center at Caltech, the Della Martin Foundation, the Conte Center for Social Decision Making at Caltech (P50MH094258), and the Boswell Foundation. The authors would also like to thank subject N.S. for participating in the studies and Kelsie Pejsa, Tessa Yao, and Viktor Scherbatyuk for technical and administrative assistance.
Publisher Copyright:
© 2017 Elsevier Inc.
PY - 2017/8/2
Y1 - 2017/8/2
N2 - To clarify the organization of motor representations in posterior parietal cortex, we test how three motor variables (body side, body part, cognitive strategy) are coded in the human anterior intraparietal cortex. All tested movements were encoded, arguing against strict anatomical segregation of effectors. Single units coded for diverse conjunctions of variables, with different dimensions anatomically overlapping. Consistent with recent studies, neurons encoding body parts exhibited mixed selectivity. This mixed selectivity resulted in largely orthogonal coding of body parts, which “functionally segregate” the effector responses despite the high degree of anatomical overlap. Body side and strategy were not coded in a mixed manner as effector determined their organization. Mixed coding of some variables over others, what we term “partially mixed coding,” argues that the type of functional encoding depends on the compared dimensions. This structure is advantageous for neuroprosthetics, allowing a single array to decode movements of a large extent of the body.
AB - To clarify the organization of motor representations in posterior parietal cortex, we test how three motor variables (body side, body part, cognitive strategy) are coded in the human anterior intraparietal cortex. All tested movements were encoded, arguing against strict anatomical segregation of effectors. Single units coded for diverse conjunctions of variables, with different dimensions anatomically overlapping. Consistent with recent studies, neurons encoding body parts exhibited mixed selectivity. This mixed selectivity resulted in largely orthogonal coding of body parts, which “functionally segregate” the effector responses despite the high degree of anatomical overlap. Body side and strategy were not coded in a mixed manner as effector determined their organization. Mixed coding of some variables over others, what we term “partially mixed coding,” argues that the type of functional encoding depends on the compared dimensions. This structure is advantageous for neuroprosthetics, allowing a single array to decode movements of a large extent of the body.
KW - Mixed selectivity
KW - anterior intraparietal cortex
KW - brain-machine interfaces
KW - functional segregation
KW - motor imagery
KW - posterior parietal cortex
KW - spinal cord injury
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U2 - 10.1016/j.neuron.2017.06.040
DO - 10.1016/j.neuron.2017.06.040
M3 - Article
C2 - 28735750
AN - SCOPUS:85025427586
SN - 0896-6273
VL - 95
SP - 697-708.e4
JO - Neuron
JF - Neuron
IS - 3
ER -