Partitioning roles of side chains in affinity, orientation, and catalysis with structures for mutant complexes: Asparagine-229 in thymidylate synthase

Medicine & Life Sciences

• 2'-deoxyuridylic acid 100%
• Thymidylate Synthase 79%
• Asparagine 74%
• Catalysis 71%
• Hydrogen Bonding 61%
• Catalytic Domain 23%
• Methylation 15%
• Cysteine 8%
• Nucleotides 6%
• Binding Sites 6%
• Water 5%
• Enzymes 4%

Chemical Compounds

• dCMP 94%
• Catalysis 38%
• Hydrogen Bond 18%
• Reaction Intermediate 6%
• Steric Effect 5%
• Cysteine 5%
• Nucleotide 4%
• Binding Site 4%
• Hydrogen 3%
• Crystal Structure 2%