Parvalbumin is a marker of ALS-resistant motor neurons

J. L. Elliott, W. D. Snider

Research output: Contribution to journalArticle

86 Citations (Scopus)

Abstract

The selective vulnerability of limb and bulbar motor neurons is a hallmark of degenerative human motor neuron diseases such as amyotrophic lateral sclerosis (ALS). Currently, there are no known molecular characteristics to distinguish between motor neuron pools which are highly susceptible to degeneration in ALS and those populations which are resistant. Using in situ hybridization on adult rat tissue, we demonstrated that ALS-resistant motor pools robustly express mRNA for the calcium binding protein parvalbumin, while no measurable parvalbumin expression is found in ALS-sensitive motor neuron populations. In contrast, mRNA expression for each of several other calcium binding proteins such as calbindin-D28K, calretinin and calmodulin appears similar in the various motor pools. Thus, parvalbumin represents a biochemical marker of ALS-resistant motor neurons, and may provide insight into the mechanisms of resistance of certain motor neurons to disease.

Original languageEnglish (US)
Pages (from-to)449-452
Number of pages4
JournalNeuroReport
Volume6
Issue number3
StatePublished - 1995

Fingerprint

Parvalbumins
Amyotrophic Lateral Sclerosis
Motor Neurons
Motor Neuron Disease
Calcium-Binding Proteins
Calbindin 1
Calbindin 2
Messenger RNA
Calmodulin
Population
In Situ Hybridization
Extremities
Biomarkers

Keywords

  • Calbindin
  • Calcium
  • Calmodulin
  • Calretinin
  • Neurodegenerative disease

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Parvalbumin is a marker of ALS-resistant motor neurons. / Elliott, J. L.; Snider, W. D.

In: NeuroReport, Vol. 6, No. 3, 1995, p. 449-452.

Research output: Contribution to journalArticle

Elliott, JL & Snider, WD 1995, 'Parvalbumin is a marker of ALS-resistant motor neurons', NeuroReport, vol. 6, no. 3, pp. 449-452.
Elliott, J. L. ; Snider, W. D. / Parvalbumin is a marker of ALS-resistant motor neurons. In: NeuroReport. 1995 ; Vol. 6, No. 3. pp. 449-452.
@article{897f3ba0a3034669ae20e2584b902554,
title = "Parvalbumin is a marker of ALS-resistant motor neurons",
abstract = "The selective vulnerability of limb and bulbar motor neurons is a hallmark of degenerative human motor neuron diseases such as amyotrophic lateral sclerosis (ALS). Currently, there are no known molecular characteristics to distinguish between motor neuron pools which are highly susceptible to degeneration in ALS and those populations which are resistant. Using in situ hybridization on adult rat tissue, we demonstrated that ALS-resistant motor pools robustly express mRNA for the calcium binding protein parvalbumin, while no measurable parvalbumin expression is found in ALS-sensitive motor neuron populations. In contrast, mRNA expression for each of several other calcium binding proteins such as calbindin-D28K, calretinin and calmodulin appears similar in the various motor pools. Thus, parvalbumin represents a biochemical marker of ALS-resistant motor neurons, and may provide insight into the mechanisms of resistance of certain motor neurons to disease.",
keywords = "Calbindin, Calcium, Calmodulin, Calretinin, Neurodegenerative disease",
author = "Elliott, {J. L.} and Snider, {W. D.}",
year = "1995",
language = "English (US)",
volume = "6",
pages = "449--452",
journal = "NeuroReport",
issn = "0959-4965",
publisher = "Lippincott Williams and Wilkins",
number = "3",

}

TY - JOUR

T1 - Parvalbumin is a marker of ALS-resistant motor neurons

AU - Elliott, J. L.

AU - Snider, W. D.

PY - 1995

Y1 - 1995

N2 - The selective vulnerability of limb and bulbar motor neurons is a hallmark of degenerative human motor neuron diseases such as amyotrophic lateral sclerosis (ALS). Currently, there are no known molecular characteristics to distinguish between motor neuron pools which are highly susceptible to degeneration in ALS and those populations which are resistant. Using in situ hybridization on adult rat tissue, we demonstrated that ALS-resistant motor pools robustly express mRNA for the calcium binding protein parvalbumin, while no measurable parvalbumin expression is found in ALS-sensitive motor neuron populations. In contrast, mRNA expression for each of several other calcium binding proteins such as calbindin-D28K, calretinin and calmodulin appears similar in the various motor pools. Thus, parvalbumin represents a biochemical marker of ALS-resistant motor neurons, and may provide insight into the mechanisms of resistance of certain motor neurons to disease.

AB - The selective vulnerability of limb and bulbar motor neurons is a hallmark of degenerative human motor neuron diseases such as amyotrophic lateral sclerosis (ALS). Currently, there are no known molecular characteristics to distinguish between motor neuron pools which are highly susceptible to degeneration in ALS and those populations which are resistant. Using in situ hybridization on adult rat tissue, we demonstrated that ALS-resistant motor pools robustly express mRNA for the calcium binding protein parvalbumin, while no measurable parvalbumin expression is found in ALS-sensitive motor neuron populations. In contrast, mRNA expression for each of several other calcium binding proteins such as calbindin-D28K, calretinin and calmodulin appears similar in the various motor pools. Thus, parvalbumin represents a biochemical marker of ALS-resistant motor neurons, and may provide insight into the mechanisms of resistance of certain motor neurons to disease.

KW - Calbindin

KW - Calcium

KW - Calmodulin

KW - Calretinin

KW - Neurodegenerative disease

UR - http://www.scopus.com/inward/record.url?scp=0028819581&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0028819581&partnerID=8YFLogxK

M3 - Article

C2 - 7766841

AN - SCOPUS:0028819581

VL - 6

SP - 449

EP - 452

JO - NeuroReport

JF - NeuroReport

SN - 0959-4965

IS - 3

ER -