PASSIVE TRANSFER OF ANTIBODIES OF MATERNAL ORIGIN FROM BLOOD TO CEREBROSPINAL FLUID IN INFANTS

JeffreyD Thorley, RandallK Holmes, J. Martin Kaplan, GeorgeH Mccracken, JayP Sanford

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

The demonstration that specific IgM antibodies are present in the serum of infants is useful in the diagnosis of several congenital infections. However, it is less certain whether the detection of antibodies in cerebrospinal fluid (C.S.F.) of infants indicates congenital infection of the central nervous system, because the origins of such antibodies have not been established. In the present study diphtheria and tetanus antitoxins of maternal origin have been detected both in the serum and in the c.s.F. of infants. These observations suggest that an important source of immunoglobulins in C.S.F. is passive transfer of antibodies from serum which should be considered in interpreting serological studies with C.S.F.

Original languageEnglish (US)
Pages (from-to)651-653
Number of pages3
JournalThe Lancet
Volume305
Issue number7908
DOIs
StatePublished - Mar 22 1975

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Passive Immunization
Cerebrospinal Fluid
Mothers
Antibodies
Diphtheria Antitoxin
Tetanus Antitoxin
Serum
Central Nervous System Infections
Immunoglobulin M
Immunoglobulins
Infection

ASJC Scopus subject areas

  • Medicine(all)

Cite this

PASSIVE TRANSFER OF ANTIBODIES OF MATERNAL ORIGIN FROM BLOOD TO CEREBROSPINAL FLUID IN INFANTS. / Thorley, JeffreyD; Holmes, RandallK; Martin Kaplan, J.; Mccracken, GeorgeH; Sanford, JayP.

In: The Lancet, Vol. 305, No. 7908, 22.03.1975, p. 651-653.

Research output: Contribution to journalArticle

Thorley, JeffreyD ; Holmes, RandallK ; Martin Kaplan, J. ; Mccracken, GeorgeH ; Sanford, JayP. / PASSIVE TRANSFER OF ANTIBODIES OF MATERNAL ORIGIN FROM BLOOD TO CEREBROSPINAL FLUID IN INFANTS. In: The Lancet. 1975 ; Vol. 305, No. 7908. pp. 651-653.
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