Passive transfer of antibodies of maternal origin from blood to cerebrospinal fluid in infants

Jeffrey D. Thorley, Randall K. Holmes, J. Martin Kaplan, George H. Mccracken, Jay P. Sanford

Research output: Contribution to journalArticle


The demonstration that specific IgM antibodies are present in the serum of infants is useful in the diagnosis of several congenital infections. However, it is less certain whether the detection of antibodies in cerebrospinal fluid (C.S.F.) of infants indicates congenital infection of the central nervous system, because the origins of such antibodies have not been established. In the present study diphtheria and tetanus antitoxins of maternal origin have been detected both in the serum and in the C.S.F. of infants. These observations suggest that an important source of immunoglobulins in C.S.F. is passive transfer of antibodies from serum which should be considered in interpreting serological studies with C.S.F.

Original languageEnglish (US)
Pages (from-to)651-653
Number of pages3
JournalUnknown Journal
Issue number7908
StatePublished - Jan 1 1975


ASJC Scopus subject areas

  • Medicine(all)

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