PAT proteins, an ancient family of lipid droplet proteins that regulate cellular lipid stores

Perry E. Bickel, John T. Tansey, Michael A. Welte

Research output: Contribution to journalArticle

418 Scopus citations

Abstract

The PAT family of lipid droplet proteins includes 5 members in mammals: perilipin, adipose differentiation-related protein (ADRP), tail-interacting protein of 47 kDa (TIP47), S3-12, and OXPAT. Members of this family are also present in evolutionarily distant organisms, including insects, slime molds and fungi. All PAT proteins share sequence similarity and the ability to bind intracellular lipid droplets, either constitutively or in response to metabolic stimuli, such as increased lipid flux into or out of lipid droplets. Positioned at the lipid droplet surface, PAT proteins manage access of other proteins (lipases) to the lipid esters within the lipid droplet core and can interact with cellular machinery important for lipid droplet biogenesis. Genetic variations in the gene for the best-characterized of the mammalian PAT proteins, perilipin, have been associated with metabolic phenotypes, including type 2 diabetes mellitus and obesity. In this review, we discuss how the PAT proteins regulate cellular lipid metabolism both in mammals and in model organisms.

Original languageEnglish (US)
Pages (from-to)419-440
Number of pages22
JournalBiochimica et Biophysica Acta - Molecular and Cell Biology of Lipids
Volume1791
Issue number6
DOIs
Publication statusPublished - Jun 2009

    Fingerprint

Keywords

  • Adipocyte
  • Lipid droplet
  • Lipogenesis
  • Lipolysis
  • PAT proteins
  • Perilipin

ASJC Scopus subject areas

  • Cell Biology
  • Molecular Biology

Cite this