Pathogenesis of HIV-associated vasculopathy

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

The vascular endothelium serves numerous diverse functions vital to the proper homeostasis of all organs. Beyond providing a conduit for oxygen delivery, the endothelium directs inflammatory cell traffic, controls thrombosis and macromolecular transport, presents a source of and target for cytokines and growth factors, and coordinates angiogenic activity. Accordingly, acute and chronic illnesses that derange endothelial function-such as diabetes mellitus, sepsis, and atherosclerosis-cause widespread, protean, and often severe manifestations of disease. To this list of systemic vascular diseases we add AIDS. The vascular endothelium is a silent target of human immunodeficiency virus-1 (HIV-1), and infection of individuals with HIV-1 results in a series of diffuse vascular processes that frequently progress unrecognized.

Original languageEnglish (US)
Title of host publicationAIDS and Heart Disease
PublisherCRC Press
Pages92-108
Number of pages17
ISBN (Electronic)9780203021897
ISBN (Print)9780824741150
StatePublished - Jan 1 2004

ASJC Scopus subject areas

  • Medicine(all)

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  • Cite this

    Terada, L. S., & Wu, R-F. (2004). Pathogenesis of HIV-associated vasculopathy. In AIDS and Heart Disease (pp. 92-108). CRC Press.