Pathogenesis of mucous membrane pemphigoid

A. Shadi Kourosh; Kim B. Yancey

doi:10.1016/j.det.2011.03.011

Pathogenesis of mucous membrane pemphigoid

A. Shadi Kourosh, Kim B. Yancey

Research output: Contribution to journal › Review article › peer-review

24 Scopus citations

Abstract

Mucous membrane pemphigoid (MMP) is the clinical phenotype of a group of autoimmune blistering diseases characterized by autoantibodies directed against different structural proteins in epidermal basement membranes. The clinical course and prognosis of MMP are affected by the specific autoantigen targeted, the titer and bioactivity profile of corresponding autoantibodies, and the specific mucosal sites of disease activity. Irreversible scarring and loss of function must be prevented by early diagnosis and appropriate interventions.

Original language	English (US)
Pages (from-to)	479-484
Number of pages	6
Journal	Dermatologic Clinics
Volume	29
Issue number	3
DOIs	https://doi.org/10.1016/j.det.2011.03.011
State	Published - Jul 1 2011

Keywords

Autoimmune
Mucous membrane
Pathogenesis
Pemphigoid

ASJC Scopus subject areas

Dermatology

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10.1016/j.det.2011.03.011

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title = "Pathogenesis of mucous membrane pemphigoid",

abstract = "Mucous membrane pemphigoid (MMP) is the clinical phenotype of a group of autoimmune blistering diseases characterized by autoantibodies directed against different structural proteins in epidermal basement membranes. The clinical course and prognosis of MMP are affected by the specific autoantigen targeted, the titer and bioactivity profile of corresponding autoantibodies, and the specific mucosal sites of disease activity. Irreversible scarring and loss of function must be prevented by early diagnosis and appropriate interventions.",

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AU - Yancey, Kim B.

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N2 - Mucous membrane pemphigoid (MMP) is the clinical phenotype of a group of autoimmune blistering diseases characterized by autoantibodies directed against different structural proteins in epidermal basement membranes. The clinical course and prognosis of MMP are affected by the specific autoantigen targeted, the titer and bioactivity profile of corresponding autoantibodies, and the specific mucosal sites of disease activity. Irreversible scarring and loss of function must be prevented by early diagnosis and appropriate interventions.

AB - Mucous membrane pemphigoid (MMP) is the clinical phenotype of a group of autoimmune blistering diseases characterized by autoantibodies directed against different structural proteins in epidermal basement membranes. The clinical course and prognosis of MMP are affected by the specific autoantigen targeted, the titer and bioactivity profile of corresponding autoantibodies, and the specific mucosal sites of disease activity. Irreversible scarring and loss of function must be prevented by early diagnosis and appropriate interventions.

KW - Autoimmune

KW - Mucous membrane

KW - Pathogenesis

KW - Pemphigoid

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JF - Dermatologic Clinics

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Pathogenesis of mucous membrane pemphigoid

Abstract

Keywords

ASJC Scopus subject areas

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