TY - JOUR
T1 - Pathogenesis of myocardial ischemia-reperfusion injury and rationale for therapy
AU - Turer, Aslan T
AU - Hill, Joseph A
N1 - Funding Information:
This work was supported by grants HL-075173 , HL-080144 , and HL-090842 from the National Institutes of Health , Bethesda, Maryland; grant 0640084N from the American Heart Association , Dallas, Texas; grant 7-08-MN-21-ADA from the American Diabetes Association , Alexandria, Virginia; and grant 0970518N from the AHA-Jon Holden DeHaan Foundation , Naples, Florida. Editorial support was funded by Schering-Plough Corporation , Kenilworth, New Jersey.
PY - 2010/8/1
Y1 - 2010/8/1
N2 - Since the initial description of the phenomenon by Jennings et al 50 years ago, our understanding of the underlying mechanisms of reperfusion injury has grown significantly. Its pathogenesis reflects the confluence of multiple pathways, including ion channels, reactive oxygen species, inflammation, and endothelial dysfunction. The purposes of this review are to examine the current state of understanding of ischemia-reperfusion injury, as well as to highlight recent interventions aimed at this heretofore elusive target. In conclusion, despite its complexity our ongoing efforts to mitigate this form of injury should not be deterred, because nearly 2 million patients annually undergo either spontaneous (in the form of acute myocardial infarction) or iatrogenic (in the context of cardioplegic arrest) ischemia-reperfusion.
AB - Since the initial description of the phenomenon by Jennings et al 50 years ago, our understanding of the underlying mechanisms of reperfusion injury has grown significantly. Its pathogenesis reflects the confluence of multiple pathways, including ion channels, reactive oxygen species, inflammation, and endothelial dysfunction. The purposes of this review are to examine the current state of understanding of ischemia-reperfusion injury, as well as to highlight recent interventions aimed at this heretofore elusive target. In conclusion, despite its complexity our ongoing efforts to mitigate this form of injury should not be deterred, because nearly 2 million patients annually undergo either spontaneous (in the form of acute myocardial infarction) or iatrogenic (in the context of cardioplegic arrest) ischemia-reperfusion.
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U2 - 10.1016/j.amjcard.2010.03.032
DO - 10.1016/j.amjcard.2010.03.032
M3 - Review article
C2 - 20643246
AN - SCOPUS:77955444881
SN - 0002-9149
VL - 106
SP - 360
EP - 368
JO - American Journal of Cardiology
JF - American Journal of Cardiology
IS - 3
ER -