Pathogenesis of non-AIDS-defining cancers: A review

Ignacio I. Wistuba, Carmen Behrens, Adi F. Gazdar

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

As the AIDS epidemic advances, the number of HIV-infected subjects developing AIDS-related neoplasms is rapidly increasing, and the spectrum of malignancies encountered is expanding. Several non-AIDS-defining cancers are being reported at an increasing incidence in HIV-infected individuals, including anal, skin, oral mucosa, head and neck and lung carcinomas, testicular tumors, and pediatric soft-tissue sarcoma. There appears to be an emerging role for various concurrent viral infections in the HIV-infected host that are likely implicated in the pathogenesis of some nondefining-AIDS neoplasms. Our recent findings in HIV-associated lung cancers and in the precursor lesions of cervical carcinoma suggest that widespread genomic instability, as manifested by the development of increased numbers of microsatellite alterations (MAs), may occur frequently in HIV-associated tumors and they may play an important role in the pathogenesis of those neoplasms. Although the mechanism underlying the development of increased MAs is unknown, it may play a crucial role in the development of many HIV- associated tumors. It will be important to track the epidemiological and biological features of non-AIDS-defining cancers in HIV-infected patients, and compare them to those tumors in the general population. It is likely that further clues about malignant transformation and oncogenesis unraveled in the HIV setting will have broad clinical implications.

Original languageEnglish (US)
Pages (from-to)415-426
Number of pages12
JournalAIDS Patient Care and STDs
Volume13
Issue number7
StatePublished - 1999

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HIV
Neoplasms
Acquired Immunodeficiency Syndrome
Microsatellite Repeats
Carcinoma
Genomic Instability
Testicular Neoplasms
Mouth Mucosa
Virus Diseases
Sarcoma
Lung Neoplasms
Carcinogenesis
Neck
Head
Pediatrics
Lung
Skin
Incidence
Population

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health
  • Leadership and Management
  • Nursing(all)

Cite this

Wistuba, I. I., Behrens, C., & Gazdar, A. F. (1999). Pathogenesis of non-AIDS-defining cancers: A review. AIDS Patient Care and STDs, 13(7), 415-426.

Pathogenesis of non-AIDS-defining cancers : A review. / Wistuba, Ignacio I.; Behrens, Carmen; Gazdar, Adi F.

In: AIDS Patient Care and STDs, Vol. 13, No. 7, 1999, p. 415-426.

Research output: Contribution to journalArticle

Wistuba, II, Behrens, C & Gazdar, AF 1999, 'Pathogenesis of non-AIDS-defining cancers: A review', AIDS Patient Care and STDs, vol. 13, no. 7, pp. 415-426.
Wistuba II, Behrens C, Gazdar AF. Pathogenesis of non-AIDS-defining cancers: A review. AIDS Patient Care and STDs. 1999;13(7):415-426.
Wistuba, Ignacio I. ; Behrens, Carmen ; Gazdar, Adi F. / Pathogenesis of non-AIDS-defining cancers : A review. In: AIDS Patient Care and STDs. 1999 ; Vol. 13, No. 7. pp. 415-426.
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