Pathogenesis of osteomalacia in secondary hyperparathyroidism after gastrectomy

Jacobo Wortsman, Charles Y C Pak, Frederic C. Bartter, Leonard Deftos, Catherine S. Delea

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Described here is a thirty-seven year old man in whom osteomalacia developed five years after subtotal gastrectomy. Gastrointestinal loss of calcium was excessive, endogenous fecal calcium secretion was high, and urinary calcium excretion was low. Circulating parathyroid hormone was present in excess and could be readily decreased by the infusion of calcium or with dihydrotachysterol; with both measures the serum phosphate level returned to normal. It is suggested that a primary defect in calcium absorption led, via a stimulus to the parathyroids, to hyperphosphaturia, hypophosphatemia nd osteomalacia; whereas calcium absorption became almost normal, gastrointestinal hypersecretion of calcium continued.

Original languageEnglish (US)
Pages (from-to)556-564
Number of pages9
JournalThe American journal of medicine
Volume52
Issue number4
DOIs
StatePublished - 1972

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Osteomalacia
Secondary Hyperparathyroidism
Gastrectomy
Calcium
Dihydrotachysterol
Familial Hypophosphatemia
Hypophosphatemia
Parathyroid Hormone
Phosphates
Serum

ASJC Scopus subject areas

  • Nursing(all)

Cite this

Pathogenesis of osteomalacia in secondary hyperparathyroidism after gastrectomy. / Wortsman, Jacobo; Pak, Charles Y C; Bartter, Frederic C.; Deftos, Leonard; Delea, Catherine S.

In: The American journal of medicine, Vol. 52, No. 4, 1972, p. 556-564.

Research output: Contribution to journalArticle

Wortsman, Jacobo ; Pak, Charles Y C ; Bartter, Frederic C. ; Deftos, Leonard ; Delea, Catherine S. / Pathogenesis of osteomalacia in secondary hyperparathyroidism after gastrectomy. In: The American journal of medicine. 1972 ; Vol. 52, No. 4. pp. 556-564.
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