Pathologic HIF1α signaling drives adipose progenitor dysfunction in obesity

Mengle Shao, Chelsea Hepler, Qianbin Zhang, Bo Shan, Lavanya Vishvanath, Gervaise H. Henry, Shangang Zhao, Yu A. An, Yibo Wu, Douglas W. Strand, Rana K. Gupta

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

How adipocyte precursor cells are regulated to control depot-specific adipose tissue expansion in obesity remains unclear. Here, Shao et al. identify a HIFα-dependent regulatory mechanism controlling adipocyte progenitor activity in mice and demonstrate the ability of the anti-cancer drug Imatinib to promote metabolically beneficial adipogenesis in obesity.

Original languageEnglish (US)
Pages (from-to)685-701.e7
JournalCell Stem Cell
Volume28
Issue number4
DOIs
StatePublished - Apr 1 2021

Keywords

  • Adipocyte precursor cell
  • Adipogenesis
  • Fibrosis
  • HIF1α
  • Imatinib
  • PDGFR
  • PPARγ

ASJC Scopus subject areas

  • Molecular Medicine
  • Genetics
  • Cell Biology

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