Pathological Gambling: A Psychobiological Study

A. Roy, B. Adinoff, L. Roehrich, D. Lamparski, R. Custer, V. Lorenz, M. Barbaccia, A. Guidotti, E. Costa, M. Linnoila

Research output: Contribution to journalArticle

190 Scopus citations


We investigated psychobiological substrates of pathological gambling by measuring levels of norepinephrine, monoamine metabolites, and peptides in cerebrospinal fluid, plasma, and urine. Pathological gamblers had a significantly higher centrally produced fraction of cerebrospinal fluid levels of 3-methoxy-4-hydroxyphenylglycol as well as significantly greater urinary outputs of norepinephrine than controls. These results suggest that pathological gamblers may have a functional disturbance of the noradrenergic system. This system has been postulated to underlie sensation-seeking behaviors, aspects of which are thought to be abnormal among pathological gamblers.

Original languageEnglish (US)
Pages (from-to)369-373
Number of pages5
JournalArchives of General Psychiatry
Issue number4
StatePublished - Apr 1988

ASJC Scopus subject areas

  • Arts and Humanities (miscellaneous)
  • Psychiatry and Mental health

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    Roy, A., Adinoff, B., Roehrich, L., Lamparski, D., Custer, R., Lorenz, V., Barbaccia, M., Guidotti, A., Costa, E., & Linnoila, M. (1988). Pathological Gambling: A Psychobiological Study. Archives of General Psychiatry, 45(4), 369-373.