TY - JOUR
T1 - Pathological Gambling
T2 - A Psychobiological Study
AU - Roy, A.
AU - Adinoff, B.
AU - Roehrich, L.
AU - Lamparski, D.
AU - Custer, R.
AU - Lorenz, V.
AU - Barbaccia, M.
AU - Guidotti, A.
AU - Costa, E.
AU - Linnoila, M.
PY - 1988/4
Y1 - 1988/4
N2 - We investigated psychobiological substrates of pathological gambling by measuring levels of norepinephrine, monoamine metabolites, and peptides in cerebrospinal fluid, plasma, and urine. Pathological gamblers had a significantly higher centrally produced fraction of cerebrospinal fluid levels of 3-methoxy-4-hydroxyphenylglycol as well as significantly greater urinary outputs of norepinephrine than controls. These results suggest that pathological gamblers may have a functional disturbance of the noradrenergic system. This system has been postulated to underlie sensation-seeking behaviors, aspects of which are thought to be abnormal among pathological gamblers.
AB - We investigated psychobiological substrates of pathological gambling by measuring levels of norepinephrine, monoamine metabolites, and peptides in cerebrospinal fluid, plasma, and urine. Pathological gamblers had a significantly higher centrally produced fraction of cerebrospinal fluid levels of 3-methoxy-4-hydroxyphenylglycol as well as significantly greater urinary outputs of norepinephrine than controls. These results suggest that pathological gamblers may have a functional disturbance of the noradrenergic system. This system has been postulated to underlie sensation-seeking behaviors, aspects of which are thought to be abnormal among pathological gamblers.
UR - http://www.scopus.com/inward/record.url?scp=0023881655&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0023881655&partnerID=8YFLogxK
U2 - 10.1001/archpsyc.1988.01800280085011
DO - 10.1001/archpsyc.1988.01800280085011
M3 - Article
C2 - 2451490
AN - SCOPUS:0023881655
SN - 0003-990X
VL - 45
SP - 369
EP - 373
JO - Archives of General Psychiatry
JF - Archives of General Psychiatry
IS - 4
ER -