Pathology Considerations in Patients Treated with Neoadjuvant Chemotherapy

Sunati Sahoo; Susan C. Lester

doi:10.1016/j.path.2012.06.005

Pathology Considerations in Patients Treated with Neoadjuvant Chemotherapy

Sunati Sahoo, Susan C. Lester

Research output: Contribution to journal › Review article › peer-review

10 Scopus citations

Abstract

Neoadjuvant therapy (NAT) originally reserved for the treatment of inflammatory and locally advanced breast cancers is currently offered to women with earlier-stage and operable breast carcinoma. NAT allows more women to be eligible for breast conservation surgery and provides an opportunity to assess the response of carcinomas to therapy. This review focuses on the predictors of therapeutic response in pretreatment tumor, evaluation of post-treatment breast and lymph node specimens and classification systems to evaluate degree of response to NAT.

Original language	English (US)
Pages (from-to)	749-774
Number of pages	26
Journal	Surgical Pathology Clinics
Volume	5
Issue number	3
DOIs	https://doi.org/10.1016/j.path.2012.06.005
State	Published - Sep 2012

Keywords

Breast cancer
Histology
NAT
Neoadjuvant therapy
Pathologic diagnosis
Preoperative therapy
Tumor markers

ASJC Scopus subject areas

Surgery
Pathology and Forensic Medicine

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10.1016/j.path.2012.06.005

Cite this

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title = "Pathology Considerations in Patients Treated with Neoadjuvant Chemotherapy",

abstract = "Neoadjuvant therapy (NAT) originally reserved for the treatment of inflammatory and locally advanced breast cancers is currently offered to women with earlier-stage and operable breast carcinoma. NAT allows more women to be eligible for breast conservation surgery and provides an opportunity to assess the response of carcinomas to therapy. This review focuses on the predictors of therapeutic response in pretreatment tumor, evaluation of post-treatment breast and lymph node specimens and classification systems to evaluate degree of response to NAT.",

keywords = "Breast cancer, Histology, NAT, Neoadjuvant therapy, Pathologic diagnosis, Preoperative therapy, Tumor markers",

author = "Sunati Sahoo and Lester, {Susan C.}",

year = "2012",

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AU - Lester, Susan C.

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AB - Neoadjuvant therapy (NAT) originally reserved for the treatment of inflammatory and locally advanced breast cancers is currently offered to women with earlier-stage and operable breast carcinoma. NAT allows more women to be eligible for breast conservation surgery and provides an opportunity to assess the response of carcinomas to therapy. This review focuses on the predictors of therapeutic response in pretreatment tumor, evaluation of post-treatment breast and lymph node specimens and classification systems to evaluate degree of response to NAT.

KW - Breast cancer

KW - Histology

KW - NAT

KW - Neoadjuvant therapy

KW - Pathologic diagnosis

KW - Preoperative therapy

KW - Tumor markers

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JO - Surgical Pathology Clinics

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ER -

Pathology Considerations in Patients Treated with Neoadjuvant Chemotherapy

Abstract

Keywords

ASJC Scopus subject areas

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