Pathology of the kidney allograft

Christopher Metter, Jose R. Torrealba

Research output: Contribution to journalReview articlepeer-review

Abstract

The kidney biopsy still represents the best approach to diagnose renal transplant complications. It is considered the gold standard in the diagnosis of rejection and non-rejection complications. Although invasive, it is a safe procedure with a very low complication rate. With adequate sampling, changes related to antibody-mediated rejection (ABMR) and T-cell mediated rejection (TCMR) can be identified. However, the pathologist needs to be aware of the many other complications, not related to rejection, that can affect the allograft function. Examples include viral infections, drug toxicity, systemic diseases such as hypertension and diabetes, and recurrent or de novo glomerulopathy, among others. In this article, we review the recent classification of pathology of the kidney allograft, with reference to recent consensus reached at the most recent Banff renal allograft classification meetings, and also highlight common non-rejection complications of the kidney transplant.

Original languageEnglish (US)
Pages (from-to)148-153
Number of pages6
JournalSeminars in Diagnostic Pathology
Volume37
Issue number3
DOIs
StatePublished - May 2020

Keywords

  • Antibody-mediated rejection
  • Cellular rejection
  • Chronic rejection
  • Kidney transplant
  • Polyoma virus
  • Rejection
  • T-cell mediated rejection

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

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