Pathophysiology and new strategies for the treatment of Legg-Calvé-Perthes disease

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Abstract

▶ Legg-Calvé-Perthes disease is a juvenile form of idiopathic osteonecrosis of the femoral head that can lead to permanent femoral head deformity and premature osteoarthritis. ▶ According to two recent multicenter, prospective cohort studies, current nonoperative and operative treatments have modest success rates of producing a good outcome with a spherical femoral head in older children with Legg- Calvé-Perthes disease. ▶ Experimental studies have revealed that the immature femoral head ismechanically weakened following ischemic necrosis. ▶ Increased bone resorption and delayed new bone formation, in combination with continued mechanical loading of the hip, contribute to the pathogenesis of the femoral head deformity. ▶ Biological treatment strategies to improve the healing process by decreasing bone resorption and stimulating bone formation appear promising in nonhuman preclinical studies.

Original languageEnglish (US)
Pages (from-to)659-669
Number of pages11
JournalJournal of Bone and Joint Surgery - Series A
Volume94
Issue number7
DOIs
Publication statusPublished - Apr 4 2012

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ASJC Scopus subject areas

  • Surgery
  • Orthopedics and Sports Medicine
  • Medicine(all)

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