Pathophysiology of anthrax

Arthur E. Frankel, Shu Ru Kuo, David Dostal, Linley Watson, Nicholas S. Duesbery, Che Ping Cheng, Heng Jie Cheng, Wei Jen Tang, Stephen H. Leppla

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

Infection by Bacillus anthracis in animals and humans results from accidental or intentional exposure, by oral, cutaneous or pulmonary routes, to spores, which are normally present in the soil. Treatment includes administration of antibiotics, vaccination or treatment with antibody to the toxin. A better understanding of the molecular basis of the processes involved in the pathogenesis of anthrax namely, spore germination in macrophages and biological effects of the secreted toxins on heart and blood vessels will lead to improved management of infected animals and patients. Controlling germination will be feasible by inhibiting macrophage paralysis and cell death. On the other hand, the control of terminal hypotension might be achieved by inhibition of cardiomyocyte mitogen-activated protein kinase and stimulation of vessel cAMP.

Original languageEnglish (US)
Pages (from-to)4516-4524
Number of pages9
JournalFrontiers in Bioscience
Volume14
Issue number12
DOIs
StatePublished - Jan 1 2009

Fingerprint

Anthrax
Macrophages
Germination
Spores
Animals
Bacillus anthracis
Blood vessels
Bacilli
Cell death
Mitogen-Activated Protein Kinases
Cardiac Myocytes
Paralysis
Hypotension
Blood Vessels
Vaccination
Cell Death
Soil
Anti-Bacterial Agents
Soils
Lung

Keywords

  • Anthrax
  • Heart failure
  • Rats
  • Review

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Immunology and Microbiology(all)
  • Medicine(all)

Cite this

Frankel, A. E., Kuo, S. R., Dostal, D., Watson, L., Duesbery, N. S., Cheng, C. P., ... Leppla, S. H. (2009). Pathophysiology of anthrax. Frontiers in Bioscience, 14(12), 4516-4524. https://doi.org/10.2741/3544

Pathophysiology of anthrax. / Frankel, Arthur E.; Kuo, Shu Ru; Dostal, David; Watson, Linley; Duesbery, Nicholas S.; Cheng, Che Ping; Cheng, Heng Jie; Tang, Wei Jen; Leppla, Stephen H.

In: Frontiers in Bioscience, Vol. 14, No. 12, 01.01.2009, p. 4516-4524.

Research output: Contribution to journalArticle

Frankel, AE, Kuo, SR, Dostal, D, Watson, L, Duesbery, NS, Cheng, CP, Cheng, HJ, Tang, WJ & Leppla, SH 2009, 'Pathophysiology of anthrax', Frontiers in Bioscience, vol. 14, no. 12, pp. 4516-4524. https://doi.org/10.2741/3544
Frankel AE, Kuo SR, Dostal D, Watson L, Duesbery NS, Cheng CP et al. Pathophysiology of anthrax. Frontiers in Bioscience. 2009 Jan 1;14(12):4516-4524. https://doi.org/10.2741/3544
Frankel, Arthur E. ; Kuo, Shu Ru ; Dostal, David ; Watson, Linley ; Duesbery, Nicholas S. ; Cheng, Che Ping ; Cheng, Heng Jie ; Tang, Wei Jen ; Leppla, Stephen H. / Pathophysiology of anthrax. In: Frontiers in Bioscience. 2009 ; Vol. 14, No. 12. pp. 4516-4524.
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