Pathophysiology of sensorineural hearing loss in jugular foramen paraganglioma

Brandon Isaacson, Cameron C. Wick, Carlos Perez, Sarah C. Cantrell, Daniel E. Killeen

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Objectives/Hypothesis: Pathologic involvement of the inferior cochlear vein is a mechanism of sensorineural hearing loss in patients with jugular foramen paraganglioma. Study Design: Retrospective case-control study. Methods: The presenting audiograms, magnetic resonance imaging, and computed tomography were reviewed in 46 subjects with jugular foramen paragangliomas. Four-frequency bone conduction average was compared between the tumor and nontumor ears in each subject to establish the presence of sensorineural hearing loss. Imaging findings for each subject were recorded. Univariate and multivariate statistical analyses were performed to determine which radiographic features were associated with sensorineural hearing loss. Hearing data were analyzed as a continuous variable and as a categorical variable. Results: Twenty subjects (43.4%) had a bone-conduction pure-tone asymmetry of greater than 15 dB. Inferior cochlear vein involvement was identified in 19 of the 20 (95%) subjects with sensorineural hearing loss. Inferior cochlear vein involvement was found to be a statistically significant predictor of sensorineural hearing loss using univariate and multivariate analyses. Other imaging findings that were statistically significant predictors of sensorineural hearing loss include Glasscock-Jackson stage, Fisch-Mattox stage, hypoglossal canal involvement, jugulo-carotid spin erosion, and petrous carotid canal erosion. Conclusions: Involvement of the inferior cochlear vein appears to be a plausible mechanism for sensorineural hearing loss in patients with jugular foramen paraganglioma. Level of Evidence: 4 Laryngoscope, 2018.

Original languageEnglish (US)
JournalLaryngoscope
DOIs
StateAccepted/In press - Jan 1 2018

Fingerprint

Paraganglioma
Sensorineural Hearing Loss
Neck
Cochlea
Veins
Bone Conduction
Multivariate Analysis
Laryngoscopes
Hearing
Ear
Case-Control Studies
Retrospective Studies
Tomography
Magnetic Resonance Imaging

Keywords

  • cochlea
  • cochlear aqueduct
  • glomus jugulare
  • hearing loss
  • inferior cochlear vein
  • Paraganglioma

ASJC Scopus subject areas

  • Otorhinolaryngology

Cite this

Pathophysiology of sensorineural hearing loss in jugular foramen paraganglioma. / Isaacson, Brandon; Wick, Cameron C.; Perez, Carlos; Cantrell, Sarah C.; Killeen, Daniel E.

In: Laryngoscope, 01.01.2018.

Research output: Contribution to journalArticle

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