Patient-Specific biomechanical modeling of cardiac amyloidosis – A case study

D. Chapelle, A. Felder, R. Chabiniok, A. Guellich, J. F. Deux, T. Damy

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

We present a patient-specific biomechanical modeling framework and an initial case study for investigating cardiac amyloidosis (CA). Our patient-specific heartbeat simulations are in good agreement with the data, and our model calibration indicates that the major effect of CA in the biophysical behavior lies in a dramatic increase of the passive stiffness. We also conducted a preliminary trial for predicting the effects of pharmacological treatments – which is an important clinical challenge – based on the model combined with a simple venous return representation. This requires further investigation and validation, albeit provides some valuable preliminary insight.

Original languageEnglish (US)
Title of host publicationFunctional Imaging and Modeling of the Heart - 8th International Conference, FIMH 2015, Proceedings
EditorsHans van Assen, Peter Bovendeerd, Hans van Assen, Peter Bovendeerd, Tammo Delhaas, Tammo Delhaas
PublisherSpringer Verlag
Pages295-303
Number of pages9
ISBN (Print)9783319203089, 9783319203089
DOIs
StatePublished - 2015
Externally publishedYes
Event8th International Conference on Functional Imaging and Modeling of the Heart, FIMH 2015 - Maastricht, Netherlands
Duration: Jun 25 2015Jun 27 2015

Publication series

NameLecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)
Volume9126
ISSN (Print)0302-9743
ISSN (Electronic)1611-3349

Other

Other8th International Conference on Functional Imaging and Modeling of the Heart, FIMH 2015
Country/TerritoryNetherlands
CityMaastricht
Period6/25/156/27/15

Keywords

  • Amyloidosis
  • Cardiac modelling
  • Heart failure
  • Patient-specific

ASJC Scopus subject areas

  • Theoretical Computer Science
  • Computer Science(all)

Fingerprint

Dive into the research topics of 'Patient-Specific biomechanical modeling of cardiac amyloidosis – A case study'. Together they form a unique fingerprint.

Cite this