Patient-Specific biomechanical modeling of cardiac amyloidosis – A case study

D. Chapelle; A. Felder; R. Chabiniok; A. Guellich; J. F. Deux; T. Damy

doi:10.1007/978-3-319-20309-6_34

Patient-Specific biomechanical modeling of cardiac amyloidosis – A case study

D. Chapelle, A. Felder, R. Chabiniok, A. Guellich, J. F. Deux, T. Damy

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

5 Scopus citations

Abstract

We present a patient-specific biomechanical modeling framework and an initial case study for investigating cardiac amyloidosis (CA). Our patient-specific heartbeat simulations are in good agreement with the data, and our model calibration indicates that the major effect of CA in the biophysical behavior lies in a dramatic increase of the passive stiffness. We also conducted a preliminary trial for predicting the effects of pharmacological treatments – which is an important clinical challenge – based on the model combined with a simple venous return representation. This requires further investigation and validation, albeit provides some valuable preliminary insight.

Original language	English (US)
Title of host publication	Functional Imaging and Modeling of the Heart - 8th International Conference, FIMH 2015, Proceedings
Editors	Hans van Assen, Peter Bovendeerd, Hans van Assen, Peter Bovendeerd, Tammo Delhaas, Tammo Delhaas
Publisher	Springer Verlag
Pages	295-303
Number of pages	9
ISBN (Print)	9783319203089, 9783319203089
DOIs	https://doi.org/10.1007/978-3-319-20309-6_34
State	Published - 2015
Externally published	Yes
Event	8th International Conference on Functional Imaging and Modeling of the Heart, FIMH 2015 - Maastricht, Netherlands Duration: Jun 25 2015 → Jun 27 2015

Publication series

Name	Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)
Volume	9126
ISSN (Print)	0302-9743
ISSN (Electronic)	1611-3349

Other

Other	8th International Conference on Functional Imaging and Modeling of the Heart, FIMH 2015
Country/Territory	Netherlands
City	Maastricht
Period	6/25/15 → 6/27/15

Keywords

Amyloidosis
Cardiac modelling
Heart failure
Patient-specific

ASJC Scopus subject areas

Theoretical Computer Science
General Computer Science

Access to Document

10.1007/978-3-319-20309-6_34

Cite this

Chapelle, D., Felder, A., Chabiniok, R., Guellich, A., Deux, J. F., & Damy, T. (2015). Patient-Specific biomechanical modeling of cardiac amyloidosis – A case study. In H. van Assen, P. Bovendeerd, H. van Assen, P. Bovendeerd, T. Delhaas, & T. Delhaas (Eds.), Functional Imaging and Modeling of the Heart - 8th International Conference, FIMH 2015, Proceedings (pp. 295-303). (Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics); Vol. 9126). Springer Verlag. https://doi.org/10.1007/978-3-319-20309-6_34

Patient-Specific biomechanical modeling of cardiac amyloidosis – A case study. / Chapelle, D.; Felder, A.; Chabiniok, R. et al.
Functional Imaging and Modeling of the Heart - 8th International Conference, FIMH 2015, Proceedings. ed. / Hans van Assen; Peter Bovendeerd; Hans van Assen; Peter Bovendeerd; Tammo Delhaas; Tammo Delhaas. Springer Verlag, 2015. p. 295-303 (Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics); Vol. 9126).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Chapelle, D, Felder, A, Chabiniok, R, Guellich, A, Deux, JF & Damy, T 2015, Patient-Specific biomechanical modeling of cardiac amyloidosis – A case study. in H van Assen, P Bovendeerd, H van Assen, P Bovendeerd, T Delhaas & T Delhaas (eds), Functional Imaging and Modeling of the Heart - 8th International Conference, FIMH 2015, Proceedings. Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics), vol. 9126, Springer Verlag, pp. 295-303, 8th International Conference on Functional Imaging and Modeling of the Heart, FIMH 2015, Maastricht, Netherlands, 6/25/15. https://doi.org/10.1007/978-3-319-20309-6_34

Chapelle D, Felder A, Chabiniok R, Guellich A, Deux JF, Damy T. Patient-Specific biomechanical modeling of cardiac amyloidosis – A case study. In van Assen H, Bovendeerd P, van Assen H, Bovendeerd P, Delhaas T, Delhaas T, editors, Functional Imaging and Modeling of the Heart - 8th International Conference, FIMH 2015, Proceedings. Springer Verlag. 2015. p. 295-303. (Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)). doi: 10.1007/978-3-319-20309-6_34

Chapelle, D. ; Felder, A. ; Chabiniok, R. et al. / Patient-Specific biomechanical modeling of cardiac amyloidosis – A case study. Functional Imaging and Modeling of the Heart - 8th International Conference, FIMH 2015, Proceedings. editor / Hans van Assen ; Peter Bovendeerd ; Hans van Assen ; Peter Bovendeerd ; Tammo Delhaas ; Tammo Delhaas. Springer Verlag, 2015. pp. 295-303 (Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)).

@inproceedings{735aa73c47a647919cf2bbcff523f2af,

title = "Patient-Specific biomechanical modeling of cardiac amyloidosis – A case study",

abstract = "We present a patient-specific biomechanical modeling framework and an initial case study for investigating cardiac amyloidosis (CA). Our patient-specific heartbeat simulations are in good agreement with the data, and our model calibration indicates that the major effect of CA in the biophysical behavior lies in a dramatic increase of the passive stiffness. We also conducted a preliminary trial for predicting the effects of pharmacological treatments – which is an important clinical challenge – based on the model combined with a simple venous return representation. This requires further investigation and validation, albeit provides some valuable preliminary insight.",

keywords = "Amyloidosis, Cardiac modelling, Heart failure, Patient-specific",

author = "D. Chapelle and A. Felder and R. Chabiniok and A. Guellich and Deux, {J. F.} and T. Damy",

note = "Publisher Copyright: {\textcopyright} Springer International Publishing Switzerland 2015.; 8th International Conference on Functional Imaging and Modeling of the Heart, FIMH 2015 ; Conference date: 25-06-2015 Through 27-06-2015",

year = "2015",

doi = "10.1007/978-3-319-20309-6_34",

language = "English (US)",

isbn = "9783319203089",

series = "Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)",

publisher = "Springer Verlag",

pages = "295--303",

editor = "{van Assen}, Hans and Peter Bovendeerd and {van Assen}, Hans and Peter Bovendeerd and Tammo Delhaas and Tammo Delhaas",

booktitle = "Functional Imaging and Modeling of the Heart - 8th International Conference, FIMH 2015, Proceedings",

}

TY - GEN

T1 - Patient-Specific biomechanical modeling of cardiac amyloidosis – A case study

AU - Chapelle, D.

AU - Felder, A.

AU - Chabiniok, R.

AU - Guellich, A.

AU - Deux, J. F.

AU - Damy, T.

N1 - Publisher Copyright: © Springer International Publishing Switzerland 2015.

PY - 2015

Y1 - 2015

N2 - We present a patient-specific biomechanical modeling framework and an initial case study for investigating cardiac amyloidosis (CA). Our patient-specific heartbeat simulations are in good agreement with the data, and our model calibration indicates that the major effect of CA in the biophysical behavior lies in a dramatic increase of the passive stiffness. We also conducted a preliminary trial for predicting the effects of pharmacological treatments – which is an important clinical challenge – based on the model combined with a simple venous return representation. This requires further investigation and validation, albeit provides some valuable preliminary insight.

AB - We present a patient-specific biomechanical modeling framework and an initial case study for investigating cardiac amyloidosis (CA). Our patient-specific heartbeat simulations are in good agreement with the data, and our model calibration indicates that the major effect of CA in the biophysical behavior lies in a dramatic increase of the passive stiffness. We also conducted a preliminary trial for predicting the effects of pharmacological treatments – which is an important clinical challenge – based on the model combined with a simple venous return representation. This requires further investigation and validation, albeit provides some valuable preliminary insight.

KW - Amyloidosis

KW - Cardiac modelling

KW - Heart failure

KW - Patient-specific

UR - http://www.scopus.com/inward/record.url?scp=84949992794&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84949992794&partnerID=8YFLogxK

U2 - 10.1007/978-3-319-20309-6_34

DO - 10.1007/978-3-319-20309-6_34

M3 - Conference contribution

AN - SCOPUS:84949992794

SN - 9783319203089

T3 - Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)

SP - 295

EP - 303

BT - Functional Imaging and Modeling of the Heart - 8th International Conference, FIMH 2015, Proceedings

A2 - van Assen, Hans

A2 - Bovendeerd, Peter

A2 - van Assen, Hans

A2 - Bovendeerd, Peter

A2 - Delhaas, Tammo

PB - Springer Verlag

T2 - 8th International Conference on Functional Imaging and Modeling of the Heart, FIMH 2015

Y2 - 25 June 2015 through 27 June 2015

ER -

Patient-Specific biomechanical modeling of cardiac amyloidosis – A case study

Abstract

Publication series

Other

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this