Pattern recognition analysis of anterior cingulated cortex blood flow to classify depression polarity

J. R C Almeida, J. Mourao-Miranda, H. J. Aizenstein, A. Versace, F. A. Kozel, H. Lu, A. Marquand, E. J. LaBarbara, M. Brammer, M. Trivedi, D. J. Kupfer, M. L. Phillips

Research output: Contribution to journalArticle

36 Scopus citations

Abstract

Differentiating bipolar from recurrent unipolar depression is a major clinical challenge. In 18 healthy females and 36 females in a depressive episode - 18 with bipolar disorder type I, 18 with recurrent unipolar depression - we applied pattern recognition analysis using subdivisions of anterior cingulate cortex (ACC) blood flow at rest, measured with arterial spin labelling. Subgenual ACC blood flow classified unipolar v. bipolar depression with 81% accuracy (83% sensitivity, 78% specificity).

Original languageEnglish (US)
Pages (from-to)310-311
Number of pages2
JournalBritish Journal of Psychiatry
Volume203
Issue number4
DOIs
StatePublished - Oct 2013

ASJC Scopus subject areas

  • Psychiatry and Mental health

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    Almeida, J. R. C., Mourao-Miranda, J., Aizenstein, H. J., Versace, A., Kozel, F. A., Lu, H., Marquand, A., LaBarbara, E. J., Brammer, M., Trivedi, M., Kupfer, D. J., & Phillips, M. L. (2013). Pattern recognition analysis of anterior cingulated cortex blood flow to classify depression polarity. British Journal of Psychiatry, 203(4), 310-311. https://doi.org/10.1192/bjp.bp.112.122838