Patterned nanomagnets on-chip for screening circulating tumor cells in blood

Yu Yen Huang, Peng Chen, Kazunori Hoshino, Chun Hsien Wu, Nancy Lane, Michael Huebschman, Jonathan Uhr, Konstantin Sokolov, Eugene Frenkel, Xiaojing Zhang

Research output: Chapter in Book/Report/Conference proceedingConference contribution

2 Scopus citations

Abstract

Circulating tumor cells (CTCs) are considered potential indicators for prognosis and clinical management. However, detection of CTCs is very challenging due to its rarity (the ratio per CTC to leukocyte is 1:10 7-109). 0We have previously developed a microchip-based immunomagnetic screening system for the isolation of CTCs from whole blood samples. The system has been successfully applied in cancer patient sample screening. Here, we report arrays of directly patterned metallic nanomagnets on a channel substrate that locally enhance magnetic field and further improve system's capture capability. The proposed screening system can be a powerful platform for the cancer management.

Original languageEnglish (US)
Title of host publicationProceedings of the 16th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2012
PublisherChemical and Biological Microsystems Society
Pages1117-1119
Number of pages3
ISBN (Print)9780979806452
StatePublished - Jan 1 2012
Event16th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2012 - Okinawa, Japan
Duration: Oct 28 2012Nov 1 2012

Publication series

NameProceedings of the 16th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2012

Other

Other16th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2012
CountryJapan
CityOkinawa
Period10/28/1211/1/12

Keywords

  • Circulating tumor cell
  • Immunomagnetic
  • Microchip
  • Nanomagnets

ASJC Scopus subject areas

  • Chemical Engineering (miscellaneous)
  • Bioengineering

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