Patterns of drug utilization in a neonatal intensive care unit

Indulekha Warrier, Wei Du, Girija Natarajan, Vali Salari, Jacob Aranda

Research output: Contribution to journalArticle

42 Scopus citations

Abstract

The objective of this study was to determine drug use in newborns at an inborn tertiary care neonatal intensive care unit, serving a predominantly African American population, to identify educational/research priorities in neonatal drug therapy. Data on demographics and exposure rates to all drugs from 6839 neonates bom between January 1997 and June 2004 were analyzed. Number of drugs used was correlated with race, gender, gestational age, birthweight, and survival status. The contribution of these factors to mean drug use was predicted by multivariate regression analysis. In this population of 80% African Americans, mean drug use was 3.6/infant, with the highest use in the 24- to 27-week gestational age group (11.7/infant). Ampicillin and cefotaxime had the highest exposure rates. Premature infants had high use of surfactant, pressor agents, and diuretics. Caucasians, males, gestational age <28 weeks, and birthweight <1000 g were the risk factors for higher drug exposure. Future research/ education must emphasize these therapeutic areas with priority assigned to low-birthweight infants.

Original languageEnglish (US)
Pages (from-to)449-455
Number of pages7
JournalJournal of clinical pharmacology
Volume46
Issue number4
DOIs
StatePublished - Apr 2006

Keywords

  • Drug utilization
  • Neonatal intensive care unit
  • Neonate

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)

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