Patterns-of-failure after helical tomotherapy-based chemoradiotherapy for head and neck cancer: Implications for CTV margin, elective nodal dose and bilateral parotid sparing

Virag Dandekar, Tiffany Morgan, Julius Turian, Mary Jo Fidler, John Showel, Thomas Nielsen, Joy Coleman, Aidnag Diaz, David J. Sher

Research output: Contribution to journalArticle

15 Scopus citations


Objectives There is debate about the optimal clinical target volume (CTV) expansion and prophylactic nodal dose (PND) in head and neck IMRT. We evaluated our patterns-of-failure (POF) after helical tomotherapy-based concurrent chemoradiotherapy (CCRT) to assess the oncologic safety of reducing the CTV, PND, and bilateral parotid sparing (BPS). Materials and Methods All patients with locally advanced squamous cell carcinoma of the head and neck treated with curative intent CCRT between January 2007 and April 2013 at a single institution were included in this retrospective study. Locoregional recurrences (LRR) were overlaid on the treatment plan, and POF was determined relative to planned dose. Results One hundred and fourteen patients treated with CCRT were evaluated, 74% of whom underwent BPS. The median follow-up for surviving patients was 29.3 months. The 3-year cumulative incidence of locoregional failure, distant metastasis, progression-free and overall survival were 20%, 20%, 56% and 73% respectively. The local failures (n = 12) were either entirely contained within or centered on the original gross tumor volume (GTV), and all but 2 regional recurrences were in GTV. There were no nodal failures in the low-dose or peri-parotid neck (including ipsilateral neck). Discussion Nearly all LRR were located within the GTV suggesting that minimal-to-zero margin is required for CTV 70. The nodal recurrence pattern suggests the safety of routine bilateral parotid sparing and relatively low biologically equivalent dose (54 Gy in 33fx) to the low-risk neck.

Original languageEnglish (US)
Pages (from-to)520-526
Number of pages7
JournalOral Oncology
Issue number5
StatePublished - May 2014



  • Combined modality therapy
  • Head and neck cancer
  • IMRT
  • Parotid sparing
  • Pattern-of-failure

ASJC Scopus subject areas

  • Oral Surgery
  • Oncology
  • Cancer Research

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