Patterns of metastatic spread following resection of extremity soft-tissue sarcomas and strategies for treatment

J. F. Huth, F. R. Eilber

Research output: Contribution to journalArticle

47 Citations (Scopus)

Abstract

This study examines recurrence patterns in 255 patients with soft-tissue sarcoma treated with preoperative chemotherapy and radiation, followed by limb-sparing surgery. Eighty-five patients developed metastatic disease: 13 had isolated local recurrence, 43 had isolated pulmonary metastases, 11 had metastases to lung and elsewhere, and 18 had metastases to multiple sites. Of the patients with isolated pulmonary metastases, 19/43 had resection of the metastases, and 9 are disease free. All 13 patients with local recurrences had resection of the recurrence, and 9 remain disease-free. Patients with multiple sites of recurrence had a 2-year survival of less than 10%. Resection of metastases is beneficial to a small number of patients who develop metastatic disease.

Original languageEnglish (US)
Pages (from-to)20-26
Number of pages7
JournalSeminars in Surgical Oncology
Volume4
Issue number1
StatePublished - 1988

Fingerprint

Sarcoma
Extremities
Neoplasm Metastasis
Recurrence
Lung
Therapeutics
Radiation
Drug Therapy
Survival

ASJC Scopus subject areas

  • Oncology
  • Surgery

Cite this

Patterns of metastatic spread following resection of extremity soft-tissue sarcomas and strategies for treatment. / Huth, J. F.; Eilber, F. R.

In: Seminars in Surgical Oncology, Vol. 4, No. 1, 1988, p. 20-26.

Research output: Contribution to journalArticle

@article{beea43d2f87c46dabba84ca3e3d89a1a,
title = "Patterns of metastatic spread following resection of extremity soft-tissue sarcomas and strategies for treatment",
abstract = "This study examines recurrence patterns in 255 patients with soft-tissue sarcoma treated with preoperative chemotherapy and radiation, followed by limb-sparing surgery. Eighty-five patients developed metastatic disease: 13 had isolated local recurrence, 43 had isolated pulmonary metastases, 11 had metastases to lung and elsewhere, and 18 had metastases to multiple sites. Of the patients with isolated pulmonary metastases, 19/43 had resection of the metastases, and 9 are disease free. All 13 patients with local recurrences had resection of the recurrence, and 9 remain disease-free. Patients with multiple sites of recurrence had a 2-year survival of less than 10{\%}. Resection of metastases is beneficial to a small number of patients who develop metastatic disease.",
author = "Huth, {J. F.} and Eilber, {F. R.}",
year = "1988",
language = "English (US)",
volume = "4",
pages = "20--26",
journal = "Journal of Surgical Oncology",
issn = "0022-4790",
publisher = "Wiley-Liss Inc.",
number = "1",

}

TY - JOUR

T1 - Patterns of metastatic spread following resection of extremity soft-tissue sarcomas and strategies for treatment

AU - Huth, J. F.

AU - Eilber, F. R.

PY - 1988

Y1 - 1988

N2 - This study examines recurrence patterns in 255 patients with soft-tissue sarcoma treated with preoperative chemotherapy and radiation, followed by limb-sparing surgery. Eighty-five patients developed metastatic disease: 13 had isolated local recurrence, 43 had isolated pulmonary metastases, 11 had metastases to lung and elsewhere, and 18 had metastases to multiple sites. Of the patients with isolated pulmonary metastases, 19/43 had resection of the metastases, and 9 are disease free. All 13 patients with local recurrences had resection of the recurrence, and 9 remain disease-free. Patients with multiple sites of recurrence had a 2-year survival of less than 10%. Resection of metastases is beneficial to a small number of patients who develop metastatic disease.

AB - This study examines recurrence patterns in 255 patients with soft-tissue sarcoma treated with preoperative chemotherapy and radiation, followed by limb-sparing surgery. Eighty-five patients developed metastatic disease: 13 had isolated local recurrence, 43 had isolated pulmonary metastases, 11 had metastases to lung and elsewhere, and 18 had metastases to multiple sites. Of the patients with isolated pulmonary metastases, 19/43 had resection of the metastases, and 9 are disease free. All 13 patients with local recurrences had resection of the recurrence, and 9 remain disease-free. Patients with multiple sites of recurrence had a 2-year survival of less than 10%. Resection of metastases is beneficial to a small number of patients who develop metastatic disease.

UR - http://www.scopus.com/inward/record.url?scp=0023866312&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0023866312&partnerID=8YFLogxK

M3 - Article

C2 - 3353620

AN - SCOPUS:0023866312

VL - 4

SP - 20

EP - 26

JO - Journal of Surgical Oncology

JF - Journal of Surgical Oncology

SN - 0022-4790

IS - 1

ER -