PCOAT: Positional correlation analysis using multiple methods

Research output: Contribution to journalArticle

5 Scopus citations

Abstract

Summary: PCOAT (Positional COrrelation Analysis Tool) is a program to perform positional correlation analysis for protein multiple sequence alignment in order to identify structurally or functionally important interactions between positions in a protein family. We implement different statistical methods to detect highly correlated position pairs, amino acid pairs, individual positions and networks of correlated positions, and utilize multiple sequence weighting and sampling methods to eliminate background correlations caused by phylogeny and stochastic events. Our program runs relatively fast and is suitable for analyzing alignments containing large number of sequences.

Original languageEnglish (US)
Pages (from-to)3697-3699
Number of pages3
JournalBioinformatics
Volume20
Issue number18
DOIs
StatePublished - Dec 12 2004

    Fingerprint

ASJC Scopus subject areas

  • Statistics and Probability
  • Biochemistry
  • Molecular Biology
  • Computer Science Applications
  • Computational Theory and Mathematics
  • Computational Mathematics

Cite this