PD-1 shapes B cells as evildoers in the tumor microenvironment

Zhenhua Ren, Hua Peng, Yang Xin Fu

Research output: Contribution to journalArticle

15 Scopus citations

Abstract

Protumorigenic PD-1hi B cells, induced in hepatocellular carcinoma, suppress tumor-specific T-cell response via IL10-dependent pathways upon PD-1/PD-L1 interaction. Anti–PD-1 or anti–PD-L1 antibodies may function not only through blocking the PD-1 coinhibitory pathway in T cells but also via abolishing the suppressive function of regulatory B cells.

Original languageEnglish (US)
Pages (from-to)477-478
Number of pages2
JournalCancer Discovery
Volume6
Issue number5
DOIs
StatePublished - May 1 2016

ASJC Scopus subject areas

  • Oncology

Fingerprint Dive into the research topics of 'PD-1 shapes B cells as evildoers in the tumor microenvironment'. Together they form a unique fingerprint.

  • Cite this