PD-1 shapes B cells as evildoers in the tumor microenvironment

Zhenhua Ren, Hua Peng, Yang Xin Fu

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Protumorigenic PD-1hi B cells, induced in hepatocellular carcinoma, suppress tumor-specific T-cell response via IL10-dependent pathways upon PD-1/PD-L1 interaction. Anti–PD-1 or anti–PD-L1 antibodies may function not only through blocking the PD-1 coinhibitory pathway in T cells but also via abolishing the suppressive function of regulatory B cells.

Original languageEnglish (US)
Pages (from-to)477-478
Number of pages2
JournalCancer Discovery
Volume6
Issue number5
DOIs
StatePublished - May 1 2016

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Tumor Microenvironment
Regulatory B-Lymphocytes
B-Lymphocytes
T-Lymphocytes
Interleukin-10
Hepatocellular Carcinoma
Antibodies
Neoplasms

ASJC Scopus subject areas

  • Oncology

Cite this

PD-1 shapes B cells as evildoers in the tumor microenvironment. / Ren, Zhenhua; Peng, Hua; Fu, Yang Xin.

In: Cancer Discovery, Vol. 6, No. 5, 01.05.2016, p. 477-478.

Research output: Contribution to journalArticle

Ren, Zhenhua ; Peng, Hua ; Fu, Yang Xin. / PD-1 shapes B cells as evildoers in the tumor microenvironment. In: Cancer Discovery. 2016 ; Vol. 6, No. 5. pp. 477-478.
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