Pecvd SiOx accelerates hydroxyapatite surface formation for enhanced early osteogenic differentiation

M. F. Velten, T. Odatsu, P. B. Aswath, N. Kamiya, H. Kim, V. G. Varanasi

Research output: Chapter in Book/Report/Conference proceedingConference contribution

1 Scopus citations

Abstract

Current metal implants are designed to structurally support the surrounding bone upon fracture. However, they have long healing times as they do not form an apatite surface layer for direct bone bonding and do not enhance osteogenesis. In this study, we use amorphous silica (SiOx) nanolayers as a potential implant coating material to improve bone healing. The aim of this study is to determine the ability of SiOx nanolayers to enhance osteogenic differentiation via rapid surface hydroxyapatite (HA) formation. SiOx nanolayers are prepared using plasma enhanced chemical vapor deposition. These nanolayers are also etched with grooves to facilitate osteoprogenitor attachment. Immersion of these nanolayers in-vitro showed a decrease in the contact angle and the presence of a hydroxyapatite layer after 6 hours. Within 1 to 3 days, these nanolayers promoted cellular attachment and extracellular matrix formation on their surfaces. Moreover, osteoprogenitor cells (human periosteum cells) had elevated levels of superoxide dismutase, bone morphogenic protein, and osterix expression which are key for the formation of a potential bone-like matrix. Thus, this study shows that SiOx nanolayers enhanced osteoprogenitor differentiation by rapidly forming HA and enhancing osteogenic marker expression during early osteoprogenitor differentiation. These nanolayers could be a potential tool for implant surface modification for enhanced bone apposition of orthopaedic and dental implants.

Original languageEnglish (US)
Title of host publicationBiomaterials Science
Subtitle of host publicationProcessing, Properties and Applications IV
EditorsSusmita Bose, Susmita Bose, Amit Bandyopadhyay, Amit Bandyopadhyay, Roger Narayan, Roger Narayan
PublisherAmerican Ceramic Society
Pages105-113
Number of pages9
ISBN (Electronic)9781118995204, 9781118995204
DOIs
StatePublished - Jan 1 2014
EventBiomaterials Science: Processing, Properties and Applications IV - Materials Science and Technology 2013 Conference and Exhibition, MS and T 2013 - Montreal, Canada
Duration: Oct 27 2013Oct 31 2013

Publication series

NameCeramic Transactions
Volume251
ISSN (Print)1042-1122

Conference

ConferenceBiomaterials Science: Processing, Properties and Applications IV - Materials Science and Technology 2013 Conference and Exhibition, MS and T 2013
CountryCanada
CityMontreal
Period10/27/1310/31/13

ASJC Scopus subject areas

  • Ceramics and Composites
  • Materials Chemistry

Fingerprint Dive into the research topics of 'Pecvd SiO<sub>x</sub> accelerates hydroxyapatite surface formation for enhanced early osteogenic differentiation'. Together they form a unique fingerprint.

  • Cite this

    Velten, M. F., Odatsu, T., Aswath, P. B., Kamiya, N., Kim, H., & Varanasi, V. G. (2014). Pecvd SiOx accelerates hydroxyapatite surface formation for enhanced early osteogenic differentiation. In S. Bose, S. Bose, A. Bandyopadhyay, A. Bandyopadhyay, R. Narayan, & R. Narayan (Eds.), Biomaterials Science: Processing, Properties and Applications IV (pp. 105-113). (Ceramic Transactions; Vol. 251). American Ceramic Society. https://doi.org/10.1002/9781118995235.ch11