Pediatric clozapine intoxication

Sallie Mady; Paul Wax; David Wang; Carla Goetz; Carmen Hadley; Raymond Love

doi:10.1016/S0735-6757(96)90152-7

Pediatric clozapine intoxication

Sallie Mady, Paul Wax, David Wang, Carla Goetz, Carmen Hadley, Raymond Love

Research output: Contribution to journal › Article › peer-review

29 Scopus citations

Abstract

Clozapine is a tricyclic dibenzodiazepine derivative used as an antipsychotic in adults. Clozapine's safety in children has not been established. This report describes three unintentional clozapine ingestions in pediatric patients. These are the first reported cases of clozapine intoxication in children. All three patients demonstrated dramatic alterations in mental status and tone, and two demonstrated extrapyramidal effects. Serum clozapine levels obtained in two patients were within the average range of steady state plasma concentrations for adults. These cases show the dramatic presentations of pediatric ingestion of clozapine and the differences between adult and pediatric intoxications.

Original language	English (US)
Pages (from-to)	462-463
Number of pages	2
Journal	American Journal of Emergency Medicine
Volume	14
Issue number	5
DOIs	https://doi.org/10.1016/S0735-6757(96)90152-7
State	Published - 1996

Keywords

Clozaril
Pediatric
altered mental status
antipsychotic
clozapine
ex trapyramidal symptoms
ingestion
intoxication
overdose

ASJC Scopus subject areas

Emergency Medicine

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10.1016/S0735-6757(96)90152-7

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title = "Pediatric clozapine intoxication",

abstract = "Clozapine is a tricyclic dibenzodiazepine derivative used as an antipsychotic in adults. Clozapine's safety in children has not been established. This report describes three unintentional clozapine ingestions in pediatric patients. These are the first reported cases of clozapine intoxication in children. All three patients demonstrated dramatic alterations in mental status and tone, and two demonstrated extrapyramidal effects. Serum clozapine levels obtained in two patients were within the average range of steady state plasma concentrations for adults. These cases show the dramatic presentations of pediatric ingestion of clozapine and the differences between adult and pediatric intoxications.",

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T1 - Pediatric clozapine intoxication

AU - Mady, Sallie

AU - Wax, Paul

AU - Wang, David

AU - Goetz, Carla

AU - Hadley, Carmen

AU - Love, Raymond

PY - 1996

Y1 - 1996

N2 - Clozapine is a tricyclic dibenzodiazepine derivative used as an antipsychotic in adults. Clozapine's safety in children has not been established. This report describes three unintentional clozapine ingestions in pediatric patients. These are the first reported cases of clozapine intoxication in children. All three patients demonstrated dramatic alterations in mental status and tone, and two demonstrated extrapyramidal effects. Serum clozapine levels obtained in two patients were within the average range of steady state plasma concentrations for adults. These cases show the dramatic presentations of pediatric ingestion of clozapine and the differences between adult and pediatric intoxications.

AB - Clozapine is a tricyclic dibenzodiazepine derivative used as an antipsychotic in adults. Clozapine's safety in children has not been established. This report describes three unintentional clozapine ingestions in pediatric patients. These are the first reported cases of clozapine intoxication in children. All three patients demonstrated dramatic alterations in mental status and tone, and two demonstrated extrapyramidal effects. Serum clozapine levels obtained in two patients were within the average range of steady state plasma concentrations for adults. These cases show the dramatic presentations of pediatric ingestion of clozapine and the differences between adult and pediatric intoxications.

KW - Clozaril

KW - Pediatric

KW - altered mental status

KW - antipsychotic

KW - clozapine

KW - ex trapyramidal symptoms

KW - ingestion

KW - intoxication

KW - overdose

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Pediatric clozapine intoxication

Abstract

Keywords

ASJC Scopus subject areas

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