Pediatric Drug Allergies: Updates on Beta-Lactam, Nonsteroidal Anti-Inflammatory Drug, and Chemotherapeutic Reactions

Shazia Lutfeali, David A Khan

Research output: Contribution to journalReview articlepeer-review

1 Scopus citations

Abstract

Adverse drug reactions are frequently reported in pediatric patients. In this review article, the authors discuss pediatric drug allergies with emphasis on the most common culprits, beta-lactam antibiotics and non-steroidal anti-inflammatory drugs. The authors also discuss reactions to non-beta-lactam antibiotics and chemotherapeutics. Skin testing has not yet been validated for many drugs, although notable exceptions include penicillin and carboplatin. The gold standard for diagnosis in most cases remains drug challenge, and the need for penicillin skin testing prior to oral provocation challenge has been questioned in recent studies. Successful desensitizations have also been reported with several drugs.

Original languageEnglish (US)
Pages (from-to)1035-1051
Number of pages17
JournalPediatric Clinics of North America
Volume66
Issue number5
DOIs
StatePublished - Oct 1 2019

Keywords

  • Beta lactam antibiotics
  • Chemotherapeutics
  • Hypersensitivity reactions
  • Non-beta lactam antibiotics
  • Nonsteroidal anti-inflammatory drugs
  • Pediatric drug allergies

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

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