Pediatric low-grade and ependymal spinal cord tumors

Thomas E. Merchant, Erin N. Kiehna, Stephen J. Thompson, Richard L. Heideman, Robert A. Sanford, Larry E. Kun

Research output: Contribution to journalArticle

69 Citations (Scopus)

Abstract

Our institutional experience with pediatric spinal cord tumors includes 25 patients with the diagnosis of ependymoma (EP; n = 4), myxopapillary ependymoma (MPEP; n = 4), juvenile pilocytic astrocytoma (JPA; n = 5), nonpilocytic astrocytoma (WHO grade I or II, n = 6), and other nonastrocytic spinal cord tumors (n = 6) treated during the period 1974-1999. Nineteen patients required radiation therapy (RT). The median progression-free survival following RT was 65 months (range 1-206 months). Seven patients recurred at an average of 22 months. The EP patients recurred at an average of 8.5 months, while the patients with low-grade astrocytoma recurred at an average of 42 months. Including the 6 nonsurviving patients, the median overall survival was 96 months. Two EP patients died with a progression-free survival of 9 months. One patient with MPEP died of other causes at 7 months. The treatment of pediatric spinal cord tumors should be individualized based on the histologic type. Radical surgery is indicated for nonmyxopapillary EP and low-grade astrocytic tumors. The need for adjuvan-therapy most often depends on the extent of resection as well as the tumor type. Patients with disseminated EP MPEP, JPA and nonpilocytic astrocytoma may achieve long-term progression-free survival with craniospinal irradiation. Copyright (C) 2000 S. Karger AG, Basel.

Original languageEnglish (US)
Pages (from-to)30-36
Number of pages7
JournalPediatric Neurosurgery
Volume32
Issue number1
DOIs
StatePublished - Jan 1 2000

Fingerprint

Spinal Cord Neoplasms
Pediatrics
Astrocytoma
Disease-Free Survival
Ependymoma
Radiotherapy
Craniospinal Irradiation
Neoplasms

Keywords

  • Astrocytoma
  • Central nervous system neoplasms
  • Craniospinal irradiation
  • Ependymoma
  • Radiotherapy
  • Spinal cord tumors

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Surgery
  • Clinical Neurology

Cite this

Merchant, T. E., Kiehna, E. N., Thompson, S. J., Heideman, R. L., Sanford, R. A., & Kun, L. E. (2000). Pediatric low-grade and ependymal spinal cord tumors. Pediatric Neurosurgery, 32(1), 30-36. https://doi.org/10.1159/000028894

Pediatric low-grade and ependymal spinal cord tumors. / Merchant, Thomas E.; Kiehna, Erin N.; Thompson, Stephen J.; Heideman, Richard L.; Sanford, Robert A.; Kun, Larry E.

In: Pediatric Neurosurgery, Vol. 32, No. 1, 01.01.2000, p. 30-36.

Research output: Contribution to journalArticle

Merchant, TE, Kiehna, EN, Thompson, SJ, Heideman, RL, Sanford, RA & Kun, LE 2000, 'Pediatric low-grade and ependymal spinal cord tumors', Pediatric Neurosurgery, vol. 32, no. 1, pp. 30-36. https://doi.org/10.1159/000028894
Merchant TE, Kiehna EN, Thompson SJ, Heideman RL, Sanford RA, Kun LE. Pediatric low-grade and ependymal spinal cord tumors. Pediatric Neurosurgery. 2000 Jan 1;32(1):30-36. https://doi.org/10.1159/000028894
Merchant, Thomas E. ; Kiehna, Erin N. ; Thompson, Stephen J. ; Heideman, Richard L. ; Sanford, Robert A. ; Kun, Larry E. / Pediatric low-grade and ependymal spinal cord tumors. In: Pediatric Neurosurgery. 2000 ; Vol. 32, No. 1. pp. 30-36.
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