@article{5a4904f0732e45fbbfe51c2d6f6a470c,
title = "Pediatric Multiple Sclerosis: From Recognition to Practical Clinical Management",
abstract = "Pediatric-onset multiple sclerosis (MS) is a rare but increasingly recognized condition that both parallels and diverges from adult-onset MS. Exposure to key risk determinants for MS disease pathogenesis may occur during childhood. The diagnosis of pediatric MS can be challenging due to potential for atypical presentations and a broad differential diagnosis. MS disease-modifying therapies have not been rigorously studied in children and raise difficult questions on how to manage a chronic inflammatory neurologic disease in a population of patients with developing central nervous and immune systems.",
keywords = "Children, Demyelination, Diagnosis, Multiple sclerosis, Treatment",
author = "Wang, {Cynthia X.} and Greenberg, {Benjamin M.}",
note = "Funding Information: Disclosures: Dr B.M. Greenberg has received research funding from the NIH (5R01NS071463-02), PCORI, MedImmune, Chugai, Genentech and the Guthy Jackson Charitable Foundation. He has received consulting fees from Novartis, Alexion and EMD Serono. C.X. Wang: No disclosures. Funding Information: Disclosures: Dr B.M. Greenberg has received research funding from the NIH ( 5R01NS071463-02 ), PCORI , MedImmune , Chugai , Genentech and the Guthy Jackson Charitable Foundation . He has received consulting fees from Novartis , Alexion and EMD Serono . C.X. Wang: No disclosures. Publisher Copyright: {\textcopyright} 2017 Elsevier Inc. Copyright: Copyright 2018 Elsevier B.V., All rights reserved.",
year = "2018",
month = feb,
doi = "10.1016/j.ncl.2017.08.005",
language = "English (US)",
volume = "36",
pages = "135--149",
journal = "Neurologic Clinics",
issn = "0733-8619",
publisher = "W.B. Saunders Ltd",
number = "1",
}