Abstract
Pediatric-onset multiple sclerosis (MS) is a rare but increasingly recognized condition that both parallels and diverges from adult-onset MS. Exposure to key risk determinants for MS disease pathogenesis may occur during childhood. The diagnosis of pediatric MS can be challenging due to potential for atypical presentations and a broad differential diagnosis. MS disease-modifying therapies have not been rigorously studied in children and raise difficult questions on how to manage a chronic inflammatory neurologic disease in a population of patients with developing central nervous and immune systems.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 135-149 |
| Number of pages | 15 |
| Journal | Neurologic Clinics |
| Volume | 36 |
| Issue number | 1 |
| DOIs | |
| State | Published - Feb 1 2018 |
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Keywords
- Children
- Demyelination
- Diagnosis
- Multiple sclerosis
- Treatment
ASJC Scopus subject areas
- Clinical Neurology
Cite this
Pediatric Multiple Sclerosis : From Recognition to Practical Clinical Management. / Wang, Cynthia X.; Greenberg, Benjamin M.
In: Neurologic Clinics, Vol. 36, No. 1, 01.02.2018, p. 135-149.Research output: Contribution to journal › Review article
}
TY - JOUR
T1 - Pediatric Multiple Sclerosis
T2 - From Recognition to Practical Clinical Management
AU - Wang, Cynthia X.
AU - Greenberg, Benjamin M.
PY - 2018/2/1
Y1 - 2018/2/1
N2 - Pediatric-onset multiple sclerosis (MS) is a rare but increasingly recognized condition that both parallels and diverges from adult-onset MS. Exposure to key risk determinants for MS disease pathogenesis may occur during childhood. The diagnosis of pediatric MS can be challenging due to potential for atypical presentations and a broad differential diagnosis. MS disease-modifying therapies have not been rigorously studied in children and raise difficult questions on how to manage a chronic inflammatory neurologic disease in a population of patients with developing central nervous and immune systems.
AB - Pediatric-onset multiple sclerosis (MS) is a rare but increasingly recognized condition that both parallels and diverges from adult-onset MS. Exposure to key risk determinants for MS disease pathogenesis may occur during childhood. The diagnosis of pediatric MS can be challenging due to potential for atypical presentations and a broad differential diagnosis. MS disease-modifying therapies have not been rigorously studied in children and raise difficult questions on how to manage a chronic inflammatory neurologic disease in a population of patients with developing central nervous and immune systems.
KW - Children
KW - Demyelination
KW - Diagnosis
KW - Multiple sclerosis
KW - Treatment
UR - http://www.scopus.com/inward/record.url?scp=85036650384&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85036650384&partnerID=8YFLogxK
U2 - 10.1016/j.ncl.2017.08.005
DO - 10.1016/j.ncl.2017.08.005
M3 - Review article
C2 - 29157395
AN - SCOPUS:85036650384
VL - 36
SP - 135
EP - 149
JO - Neurologic Clinics
JF - Neurologic Clinics
SN - 0733-8619
IS - 1
ER -