Abstract
Pediatric-onset multiple sclerosis (MS) is a rare but increasingly recognized condition that both parallels and diverges from adult-onset MS. Exposure to key risk determinants for MS disease pathogenesis may occur during childhood. The diagnosis of pediatric MS can be challenging due to potential for atypical presentations and a broad differential diagnosis. MS disease-modifying therapies have not been rigorously studied in children and raise difficult questions on how to manage a chronic inflammatory neurologic disease in a population of patients with developing central nervous and immune systems.
Original language | English (US) |
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Pages (from-to) | 135-149 |
Number of pages | 15 |
Journal | Neurologic Clinics |
Volume | 36 |
Issue number | 1 |
DOIs | |
State | Published - Feb 2018 |
Keywords
- Children
- Demyelination
- Diagnosis
- Multiple sclerosis
- Treatment
ASJC Scopus subject areas
- Clinical Neurology