With the increased application of many different drug classes for the treatment of psychiatric conditions in children, the incidence of priapism has also increased. Priapism of pharmacotherapeutic etiology in the pediatric population is a complex and poorly understood entity that continues to present new management challenges for clinicians. We present 2 cases of pediatric priapism thought to be secondary to the use of pharmacotherapeutic agents. In the first case, sertraline, an antidepressant, and in the second case, atomoxetine, a nonstimulant medication, are implicated as the most likely causative agents. Both medications have a growing association with priapism in the literature.
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