TY - JOUR
T1 - Pediatric rheumatology for the adult rheumatologist II
T2 - Uveitis in juvenile idiopathic arthritis
AU - Wright, Tracey
AU - Cron, Randy Q.
PY - 2007/8
Y1 - 2007/8
N2 - Uveitis is an important and frequent extra-articular manifestation of juvenile idiopathic arthritis (JIA) that may result in poor visual outcome. Without early detection and aggressive therapy, the uveitis and topical steroid therapy used to treat it may result in cataracts, glaucoma, and even blindness. Fortunately, a variety of systemically administered anti-inflammatory agents have been found useful for the treatment of JIA associated uveitis. Methotrexate is often the first line disease modifying systemic agent used to help wean topical corticosteroids, but when this is not sufficiently effective there are a variety of other systemic medicines available. In particular, one of the tumor necrosis factor-α inhibitors, infliximab, has shown some promising results in difficult to treat JIA associated uveitis. With early screening and detection combined with aggressive therapy in difficult to treat cases, the morbidity associated with uveitis as part of JIA is on the decline.
AB - Uveitis is an important and frequent extra-articular manifestation of juvenile idiopathic arthritis (JIA) that may result in poor visual outcome. Without early detection and aggressive therapy, the uveitis and topical steroid therapy used to treat it may result in cataracts, glaucoma, and even blindness. Fortunately, a variety of systemically administered anti-inflammatory agents have been found useful for the treatment of JIA associated uveitis. Methotrexate is often the first line disease modifying systemic agent used to help wean topical corticosteroids, but when this is not sufficiently effective there are a variety of other systemic medicines available. In particular, one of the tumor necrosis factor-α inhibitors, infliximab, has shown some promising results in difficult to treat JIA associated uveitis. With early screening and detection combined with aggressive therapy in difficult to treat cases, the morbidity associated with uveitis as part of JIA is on the decline.
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U2 - 10.1097/RHU.0b013e31813c0e36
DO - 10.1097/RHU.0b013e31813c0e36
M3 - Review article
C2 - 17762455
AN - SCOPUS:34548439843
SN - 1076-1608
VL - 13
SP - 205
EP - 210
JO - Journal of Clinical Rheumatology
JF - Journal of Clinical Rheumatology
IS - 4
ER -