TY - JOUR
T1 - PEGylated polypyrrole nanoparticles conjugating gadolinium chelates for dual-modal MRI/photoacoustic imaging guided photothermal therapy of cancer
AU - Liang, Xiaolong
AU - Li, Yanyan
AU - Li, Xiaoda
AU - Jing, Lijia
AU - Deng, Zijian
AU - Yue, Xiuli
AU - Li, Changhui
AU - Dai, Zhifei
N1 - Publisher Copyright:
© 2015 Wiley-VCH Verlag GmbH & Co. KGaA.
PY - 2015/3/4
Y1 - 2015/3/4
N2 - Polypyrrole nanoparticles conjugating gadolinium chelates were successfully fabricated for dual-modal magnetic resonance imaging (MRI) and photoacoustic imaging guided photothermal therapy of cancer, from a mixture of pyrrole and pyrrole-1-propanoic acid through a facile one-step aqueous dispersion polymerization, followed by covalent attachment of gadolinium chelate, using polyethylene glycol as a linker. The obtained PEGylated poly-pyrrole nanoparticles conjugating gadolinium chelates (Gd-PEG-PPy NPs), sized around around 70 nm, exhibited a high T1 relaxivity coefficient of 10.61 L m M-1 s-1, more than twice as high as that of the relating free Gd3+complex (4.2 L m M-1 s-1). After 24 h intravenous injection of Gd-PEG-PPy NPs, the tumor sites exhibited obvious enhancement in both T1-weighted MRI intensity and photoacoustic signal compared with that before injection, indicating the efficient accumulation of Gd-PEG-PPy NPs due to the introduction of the PEG layer onto the particle surface. In addition, tumor growth could be effectively inhibited after treatment with Gd-PEG-PPy NPs in combination with near-infrared laser irradiation. The passive targeting and high MRI/photoacoustic contrast capability of Gd-PEG-PPy NPs are quite favorable for precise cancer diagnosing and locating the tumor site to guide the external laser irradiation for photothermal ablation of tumors without damaging the surrounding healthy tissues. Therefore, Gd-PEG-PPy NPs may assist in better monitoring the therapeutic process, and contribute to developing more effective "personalized medicine," showing great potential for cancer diagnosis and therapy.
AB - Polypyrrole nanoparticles conjugating gadolinium chelates were successfully fabricated for dual-modal magnetic resonance imaging (MRI) and photoacoustic imaging guided photothermal therapy of cancer, from a mixture of pyrrole and pyrrole-1-propanoic acid through a facile one-step aqueous dispersion polymerization, followed by covalent attachment of gadolinium chelate, using polyethylene glycol as a linker. The obtained PEGylated poly-pyrrole nanoparticles conjugating gadolinium chelates (Gd-PEG-PPy NPs), sized around around 70 nm, exhibited a high T1 relaxivity coefficient of 10.61 L m M-1 s-1, more than twice as high as that of the relating free Gd3+complex (4.2 L m M-1 s-1). After 24 h intravenous injection of Gd-PEG-PPy NPs, the tumor sites exhibited obvious enhancement in both T1-weighted MRI intensity and photoacoustic signal compared with that before injection, indicating the efficient accumulation of Gd-PEG-PPy NPs due to the introduction of the PEG layer onto the particle surface. In addition, tumor growth could be effectively inhibited after treatment with Gd-PEG-PPy NPs in combination with near-infrared laser irradiation. The passive targeting and high MRI/photoacoustic contrast capability of Gd-PEG-PPy NPs are quite favorable for precise cancer diagnosing and locating the tumor site to guide the external laser irradiation for photothermal ablation of tumors without damaging the surrounding healthy tissues. Therefore, Gd-PEG-PPy NPs may assist in better monitoring the therapeutic process, and contribute to developing more effective "personalized medicine," showing great potential for cancer diagnosis and therapy.
UR - http://www.scopus.com/inward/record.url?scp=85027927918&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85027927918&partnerID=8YFLogxK
U2 - 10.1002/adfm.201402338
DO - 10.1002/adfm.201402338
M3 - Article
AN - SCOPUS:85027927918
SN - 1616-301X
VL - 25
SP - 1451
EP - 1462
JO - Advanced Functional Materials
JF - Advanced Functional Materials
IS - 9
ER -