Pemphigoid: Clinical, histologic, immunopathologic, and therapeutic considerations

Kim B. Yancey, Conleth A. Egan

Research output: Contribution to journalArticle

103 Citations (Scopus)

Abstract

Autoimmune blistering diseases are generally distinct entities characterized by relatively consistent clinical, histologic, and immunopathologic findings. These disorders may cause impaired adhesion of epidermis to epidermal basement membrane (eg, the pemphigoid group of disorders [bullous, gestational, and mucous membrane]) or impaired adhesion of epidermal cells to each other (eg, the pemphigus group of disorders). Recent studies have shown that these disorders are characterized by autoantibodies that often display pathogenic (ie, blister-forming) activity in passive transfer models. Interestingly, the autoantigens targeted by these patients' autoantibodies represent important structural proteins that promote cell matrix (eg, pemphigoid) or cell-to-cell (eg, pemphigus) adhesion in skin. Autoimmune blistering diseases are characterized by substantial morbidity (pruritus, pain, disfigurement), and in some instances, mortality (secondary to loss of epidermal barrier function). Treatment with systemic immunosuppressives has reduced morbidity and mortality in patients with these diseases.

Original languageEnglish (US)
Pages (from-to)350-356
Number of pages7
JournalJournal of the American Medical Association
Volume284
Issue number3
StatePublished - Jul 19 2000

Fingerprint

Bullous Pemphigoid
Pemphigus
Autoantibodies
Autoimmune Diseases
Morbidity
Mortality
Autoantigens
Blister
Pruritus
Immunosuppressive Agents
Basement Membrane
Epidermis
Cell Adhesion
Mucous Membrane
Therapeutics
Pain
Skin
Proteins

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Pemphigoid : Clinical, histologic, immunopathologic, and therapeutic considerations. / Yancey, Kim B.; Egan, Conleth A.

In: Journal of the American Medical Association, Vol. 284, No. 3, 19.07.2000, p. 350-356.

Research output: Contribution to journalArticle

@article{84f8c9f9313649a1a05b1fb737763ec3,
title = "Pemphigoid: Clinical, histologic, immunopathologic, and therapeutic considerations",
abstract = "Autoimmune blistering diseases are generally distinct entities characterized by relatively consistent clinical, histologic, and immunopathologic findings. These disorders may cause impaired adhesion of epidermis to epidermal basement membrane (eg, the pemphigoid group of disorders [bullous, gestational, and mucous membrane]) or impaired adhesion of epidermal cells to each other (eg, the pemphigus group of disorders). Recent studies have shown that these disorders are characterized by autoantibodies that often display pathogenic (ie, blister-forming) activity in passive transfer models. Interestingly, the autoantigens targeted by these patients' autoantibodies represent important structural proteins that promote cell matrix (eg, pemphigoid) or cell-to-cell (eg, pemphigus) adhesion in skin. Autoimmune blistering diseases are characterized by substantial morbidity (pruritus, pain, disfigurement), and in some instances, mortality (secondary to loss of epidermal barrier function). Treatment with systemic immunosuppressives has reduced morbidity and mortality in patients with these diseases.",
author = "Yancey, {Kim B.} and Egan, {Conleth A.}",
year = "2000",
month = "7",
day = "19",
language = "English (US)",
volume = "284",
pages = "350--356",
journal = "JAMA - Journal of the American Medical Association",
issn = "0098-7484",
publisher = "American Medical Association",
number = "3",

}

TY - JOUR

T1 - Pemphigoid

T2 - Clinical, histologic, immunopathologic, and therapeutic considerations

AU - Yancey, Kim B.

AU - Egan, Conleth A.

PY - 2000/7/19

Y1 - 2000/7/19

N2 - Autoimmune blistering diseases are generally distinct entities characterized by relatively consistent clinical, histologic, and immunopathologic findings. These disorders may cause impaired adhesion of epidermis to epidermal basement membrane (eg, the pemphigoid group of disorders [bullous, gestational, and mucous membrane]) or impaired adhesion of epidermal cells to each other (eg, the pemphigus group of disorders). Recent studies have shown that these disorders are characterized by autoantibodies that often display pathogenic (ie, blister-forming) activity in passive transfer models. Interestingly, the autoantigens targeted by these patients' autoantibodies represent important structural proteins that promote cell matrix (eg, pemphigoid) or cell-to-cell (eg, pemphigus) adhesion in skin. Autoimmune blistering diseases are characterized by substantial morbidity (pruritus, pain, disfigurement), and in some instances, mortality (secondary to loss of epidermal barrier function). Treatment with systemic immunosuppressives has reduced morbidity and mortality in patients with these diseases.

AB - Autoimmune blistering diseases are generally distinct entities characterized by relatively consistent clinical, histologic, and immunopathologic findings. These disorders may cause impaired adhesion of epidermis to epidermal basement membrane (eg, the pemphigoid group of disorders [bullous, gestational, and mucous membrane]) or impaired adhesion of epidermal cells to each other (eg, the pemphigus group of disorders). Recent studies have shown that these disorders are characterized by autoantibodies that often display pathogenic (ie, blister-forming) activity in passive transfer models. Interestingly, the autoantigens targeted by these patients' autoantibodies represent important structural proteins that promote cell matrix (eg, pemphigoid) or cell-to-cell (eg, pemphigus) adhesion in skin. Autoimmune blistering diseases are characterized by substantial morbidity (pruritus, pain, disfigurement), and in some instances, mortality (secondary to loss of epidermal barrier function). Treatment with systemic immunosuppressives has reduced morbidity and mortality in patients with these diseases.

UR - http://www.scopus.com/inward/record.url?scp=0034686674&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0034686674&partnerID=8YFLogxK

M3 - Article

C2 - 10891967

AN - SCOPUS:0034686674

VL - 284

SP - 350

EP - 356

JO - JAMA - Journal of the American Medical Association

JF - JAMA - Journal of the American Medical Association

SN - 0098-7484

IS - 3

ER -