Penetrating keratoplasty for exogenous paecilomyces keratitis followed by postoperative endophthalmitis

Alan M. Kozarsky, R. Doyle Stulting, George O. Waring, F. Michael Cornell, Louis A. Wilson, Harrison D Cavanagh

Research output: Contribution to journalArticle

35 Citations (Scopus)

Abstract

Three patients developed Paecilomyces lilacinus keratitis while being treated with topical corticosteroids and antibiotics. The first patient, a diabetic man, suffered superficial ocular trauma while being treated for recurrent anterior uveitis related to an iris-fixated intraocular lens. The second patient developed keratitis while being treated for anterior segment inflammation associated with herpes zoster ophthalmicus. The third patient, a woman with chronic lymphoma in remission, was receiving topical antibiotics and corticosteroids for a corneal transplant performed one year previously. All three patients underwent penetrating keratoplasty after progression to perforation or failure of medical therapy. Two eyes (cases 1 and 2) eventually required enucleation. The fungal isolates demonstrated in vitro resistance to amphotericin and natamycin with greater sensitivity to imidazole derivatives. Thus, we recommend prompt and prolonged topical treatment with miconazole or other imidazole derivatives along with avoidance of penetrating keratoplasty and corticosteroids.

Original languageEnglish (US)
Pages (from-to)552-557
Number of pages6
JournalAmerican Journal of Ophthalmology
Volume98
Issue number5
StatePublished - 1984

Fingerprint

Paecilomyces
Penetrating Keratoplasty
Endophthalmitis
Keratitis
Adrenal Cortex Hormones
Herpes Zoster Ophthalmicus
Natamycin
Anti-Bacterial Agents
Miconazole
Anterior Uveitis
Intraocular Lenses
Amphotericin B
Iris
Lymphoma
Inflammation
Transplants
Wounds and Injuries
Therapeutics

ASJC Scopus subject areas

  • Ophthalmology

Cite this

Kozarsky, A. M., Stulting, R. D., Waring, G. O., Cornell, F. M., Wilson, L. A., & Cavanagh, H. D. (1984). Penetrating keratoplasty for exogenous paecilomyces keratitis followed by postoperative endophthalmitis. American Journal of Ophthalmology, 98(5), 552-557.

Penetrating keratoplasty for exogenous paecilomyces keratitis followed by postoperative endophthalmitis. / Kozarsky, Alan M.; Stulting, R. Doyle; Waring, George O.; Cornell, F. Michael; Wilson, Louis A.; Cavanagh, Harrison D.

In: American Journal of Ophthalmology, Vol. 98, No. 5, 1984, p. 552-557.

Research output: Contribution to journalArticle

Kozarsky, AM, Stulting, RD, Waring, GO, Cornell, FM, Wilson, LA & Cavanagh, HD 1984, 'Penetrating keratoplasty for exogenous paecilomyces keratitis followed by postoperative endophthalmitis', American Journal of Ophthalmology, vol. 98, no. 5, pp. 552-557.
Kozarsky, Alan M. ; Stulting, R. Doyle ; Waring, George O. ; Cornell, F. Michael ; Wilson, Louis A. ; Cavanagh, Harrison D. / Penetrating keratoplasty for exogenous paecilomyces keratitis followed by postoperative endophthalmitis. In: American Journal of Ophthalmology. 1984 ; Vol. 98, No. 5. pp. 552-557.
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